地骨皮甲素是結(jié)構(gòu)獨特的精胺類生物堿，為地骨皮的主要活性成分，具有抗氧化、抗炎、神經(jīng)保護、抗腫瘤、降血糖、降血壓、調(diào)血脂、抗蟲、抗帕金森癥等藥理作用?，F(xiàn)有文獻對地骨皮甲素在神經(jīng)保護、抗氧化、抗炎方面的研究比較完善；但存在缺乏抗菌、抗病毒的研究，降血壓方面缺乏具體機制研究，神經(jīng)退行性疾病研究不全面等不足。對近年來國內(nèi)外地骨皮甲素的藥理作用進行了綜述，以期為后續(xù)研究和進一步藥用開發(fā)提供參考。

Kukoamine A is a phenolic amide alkaloid in the active ingredients of Cortex Lycii Radicis, which has a unique chemical structure, and it has pharmacological effects such as antioxidant, anti-inflammatory, neuroprotective, antitumor, hypoglycemic, antihypertensive, lipid-lowering, insect-resistant, and Parkinson's disease-resistant, so it has great development value. It was found that the research on neuroprotection, antioxidation and anti-inflammation of kukoamine A is relatively complete; However, there are some deficiencies such as lack of research on antibacterial and antiviral, lack of specific mechanism research on blood pressure lowering, and incomplete research on neurodegenerative diseases.The researches on the pharmacological effects of kukoamine A at home and abroad in recent years were reviewed in order to provide reference for subsequent research and further pharmaceutical development.

R285.5

“十三五”南京市衛(wèi)生青年人才培養(yǎng)第三層次資助項目(QRX17132)