目的 系統(tǒng)評(píng)價(jià)健胃消食口服液聯(lián)合多潘立酮治療兒童功能性消化不良的臨床療效及安全性。方法 計(jì)算機(jī)檢索中國(guó)學(xué)術(shù)期刊全文數(shù)據(jù)庫(kù)（CNKI）、萬(wàn)方數(shù)據(jù)知識(shí)服務(wù)平臺(tái)（Wanfang Data）、維普中文科技期刊數(shù)據(jù)庫(kù)（VIP）、中國(guó)生物醫(yī)學(xué)文獻(xiàn)服務(wù)系統(tǒng)（SinoMed）、The Cochrane Library、PubMed和Web of Science等數(shù)據(jù)庫(kù)，收集自建庫(kù)起至2022年1月22日健胃消食口服液聯(lián)合多潘立酮治療兒童功能性消化不良的臨床隨機(jī)對(duì)照試驗(yàn)（RCT），使用RevMan 5.4軟件進(jìn)行Meta分析。結(jié)果 共納入12項(xiàng)RCTs、包括1 417例患兒，Meta分析結(jié)果顯示：健胃消食口服液聯(lián)合多潘立酮組較單獨(dú)使用多潘立酮（對(duì)照）組能縮短患兒食欲恢復(fù)時(shí)間［MD＝-2.06，95% CI（-2.32，-1.81）］、惡心嘔吐消失時(shí)間［MD＝-2.07，95% CI（-2.34，-1.70）］、提高總有效率［RR＝1.26，95% CI（1.20，1.33）］，兩組比較差異均有統(tǒng)計(jì)學(xué)意義（P<0.000 01）；不良反應(yīng)率［RR＝0.71，95% CI（0.44，1.14），P＝0.16］，兩組比較差異無(wú)統(tǒng)計(jì)學(xué)意義。結(jié)論 健胃消食口服液聯(lián)合多潘立酮治療兒童功能性消化不良的療效優(yōu)于單用多潘立酮，且安全性沒(méi)有明顯差別。

Objective To systematically evaluate the clinical efficacy and safety of Jianweixiaoshi Oral Liquid combined with domperidone in the treatment of functional dyspepsia in children. Methods Data were electronically searched from the CNKI, Wanfang Data, VIP, SinoMed, The Cochrane Library, PubMed, and Web of Science, in order to collect the randomized controlled trials (RCTs) on Jianweixiaoshi Oral Liquid combined with domperidone in the treatment of functional dyspepsia in children. The search time was from the establishment of the database to 22, January 2022. The Meta-analysis was carried out by RevMan 5.4 software. Results A total of 12 RCTs were selected, including 1 417 children with functional dyspepsia. The Meta-analysis results that compared with domperidone alone (control) group, Jianweixiaoshi Oral Liquid combined with domperidone group could reduce the appetite recovery time[MD=-2.06, 95%CI (-2.32, -1.81)], reduce the disappearance time of nausea and vomiting[MD=-2.07, 95%CI (-2.34, -1.70)], increase total effective rate[RR=4.61, 95%CI (3.23, 6.57)], the differences are statistically significant (P<0.000 01). There was no statistically significant in adverse reaction rate between two groups[RR=0.71, 95%CI (0.44, 1.14), P=0.16]. Conclusion Jianweixiaoshi Oral Liquid combined with domperidone is more effective than Domperidone alone in the treatment of children with functional dyspepsia, and there is no significant difference in safety.

國(guó)家自然科學(xué)基金青年基金資助項(xiàng)目（82004422）