敗醬草來源于敗醬科草本植物黃花敗醬Patrinia scabiosaefolia和白花敗醬P.villosa的帶根全草，其乙醇提取物在動(dòng)物體內(nèi)外實(shí)驗(yàn)中均表現(xiàn)出明顯的抗結(jié)直腸癌作用，抗腫瘤的主要活性成分為黃酮類和皂苷類。敗醬草抗結(jié)直腸癌藥理作用機(jī)制主要是抑制結(jié)直腸癌細(xì)胞增殖并誘導(dǎo)其凋亡，抑制腫瘤血管生成，調(diào)控相關(guān)蛋白表達(dá)，調(diào)節(jié)信號(hào)傳導(dǎo)通路，逆轉(zhuǎn)結(jié)直腸癌細(xì)胞耐藥及調(diào)節(jié)機(jī)體免疫功能。對(duì)敗醬草及其有效成分抗結(jié)直腸癌的藥理作用機(jī)制進(jìn)行綜述，以期為抗結(jié)直腸癌新藥研發(fā)提供參考。

Herba Patriniae is a root grass of herbaceous plants Patrinia scabiosaefolia Fisch and P. villosa Juss, the ethanol extract of it showed remarkable anti-cancer effects both in vitro and in vivo, the main active components of anti-tumor are flavonoids and saponins. The pharmacological mechanism of anti-colorectal cancer of the Herba Patriniae is mainly to inhibit the proliferation of colorectal cancer cells and induce their apoptosis, inhibit tumor angiogenesis, regulate the expression of related proteins, regulate signaling pathways, reverse colorectal cancer cell resistance and regulate the body's immune function. The pharmacological mechanism of anti-colorectal cancer of the Herba Patriniae and its active ingredients is reviewed, in order to provide a reference for the research and development of new drugs against colorectal cancer.

國家自然科學(xué)基金資助項(xiàng)目（82104553）