[關(guān)鍵詞]
[摘要]
姜黃素(curcumin)是從姜黃中提取的多酚化合物,具有抗腫瘤、抗炎、抗菌等廣泛的藥理活性,但其溶解度低、生物利用度差、藥動(dòng)學(xué)差,限制了該藥的臨床應(yīng)用。近年來,基于納米技術(shù)的藥物遞送系統(tǒng)(主要包括納米顆粒、脂質(zhì)體、膠束、聚合物、納米凝膠等)有效改善了姜黃素的生物利用度和溶解性,提高了體內(nèi)藥物活性。就姜黃素納米制劑在消化系統(tǒng)腫瘤(胃癌、肝癌、結(jié)直腸癌、胰腺癌和食管癌)中的應(yīng)用進(jìn)行綜述,旨在為姜黃素納米制劑的進(jìn)一步研究與利用提供參考。
[Key word]
[Abstract]
Curcumin, a polyphenol compound extracted from Curcuma longa L., has a wide range of pharmacological properties such as anti-tumor, anti-inflammatory and antibacterial. However, its low solubility, poor bioavailability and poor pharmacokinetics which limit its therapeutic application. In recent years, the drug delivery system based on nanotechnology has effectively improved the bioavailability and solubility of curcumin, and improved the activity of this natural drug, mainly including nanoparticles, liposomes, micelles, polymers, and nanogels. This article reviews the application of curcumin nanoparticles in digestive system tumors (gastric cancer, liver cancer, colorectal cancer, pancreatic cancer and esophageal cancer), aiming to provide reference for further research and utilization of curcumin.
[中圖分類號(hào)]
[基金項(xiàng)目]