代謝性疾病發(fā)病緩慢且難以治愈，包括代謝相關(guān)脂肪性肝病、糖尿病、痛風(fēng)等。萊菔硫烷是廣泛存在于十字花科植物的異硫氰酸鹽類化合物，具有抗炎、抗氧化、抗腫瘤等多種生物活性，而且可以通過減少脂肪積累、改善線粒體功能障礙、調(diào)節(jié)氧化平衡以及減少炎癥因子表達(dá)對代謝性疾病發(fā)揮調(diào)節(jié)作用。對菜菔硫烷調(diào)節(jié)代謝性疾病的藥理作用機(jī)制進(jìn)行總結(jié)，以期為食源性植物化學(xué)成分用于代謝性疾病的預(yù)防和治療提供新思路。

Metabolic diseases are slow in onset and difficult to cure, including metabolic related fatty liver disease, diabetes and gout. Sulforaphane is a kind of isothiocyanate compound widely existing in Cruciferae plants, which has many biological activities such as anti-inflammatory, anti-oxidation and anti-tumor. Pharmacological studies have found that sulforaphane can play a regulatory role in metabolic diseases by reducing fat accumulation, improving mitochondrial dysfunction, regulating oxidative balance and reducing the expression of inflammatory factors. The pharmacological mechanism of sulforaphane in regulating metabolic diseases was summarized in order to provide new ideas for the prevention and treatment of food borne phytochemical components and metabolic diseases.

R285.5

國家自然科學(xué)基金面上資助項(xiàng)目（81573135）；黑龍江省教育廳科學(xué)技術(shù)研究項(xiàng)目（12541763）；黑龍江中醫(yī)藥大學(xué)研究生創(chuàng)新科研項(xiàng)目（2022yjscx013）