厚樸酚及和厚樸酚是一對(duì)疏水性烯丙基聯(lián)苯酚類結(jié)構(gòu)的同分異構(gòu)體，具有許多相同的藥理作用，如抗炎、抗氧化、抗腫瘤、抗微生物等。厚樸酚及和厚樸酚是鈣離子通道阻滯劑，能抑制胃腸道平滑肌收縮；也能促進(jìn)胃動(dòng)素和胃泌素分泌，增強(qiáng)胃腸道內(nèi)Cajal間質(zhì)細(xì)胞內(nèi)質(zhì)網(wǎng)上的三磷酸肌醇受體和蘭尼堿受體的表達(dá)和受體活性，促進(jìn)內(nèi)質(zhì)網(wǎng)釋放鈣離子，激活Cajal間質(zhì)細(xì)胞的起搏電流，增強(qiáng)胃腸道的節(jié)律性收縮。因此。厚樸酚及和厚樸酚對(duì)胃排空和胃腸推進(jìn)運(yùn)動(dòng)產(chǎn)生雙向調(diào)節(jié)作用：當(dāng)各種病理因子引起胃腸道運(yùn)動(dòng)功能低下時(shí)表現(xiàn)為促進(jìn)胃排空和胃腸推進(jìn)運(yùn)動(dòng)；當(dāng)各種病理因子引起胃腸運(yùn)動(dòng)亢進(jìn)時(shí)，表現(xiàn)為對(duì)抗亢進(jìn)。加之它們的抗氧化和抗炎作用可保護(hù)腸黏膜免遭傷害，提高膿毒癥所致的胃腸道運(yùn)動(dòng)障礙，也能對(duì)抗各種腸炎和瀉藥所致的腹瀉。

Magnolol and honokiol are hydrophotic isomer of propenyl biphenol-type structure. They have many identical pharmacologic actions, including anti-inflammation, antioxidation, anticancer, anti-microbe. Magnolol and honokiol are Ca²⁺ channel blockers, to inhibit contraction of isoleted gastrointestinal smooth muscle. Magnolol and honokiol promote secretion of motilin and gastrin, and increase the expression and activity of IP3R and RyR on endoplasmic reticulum in gastrointestinal interstilial cells of Cajal to accelerate Ca²⁺ release from endoplasmic reticulum, and activate pacemaker currents of Cajal cells, and to enhance rhythmic contraction of gastrointestinal tract. Thus magnolol and honokiol have dual-directional regulation to gastric emptying and gastrointestinal propulsion movement, when various pathological factors induce hypofunction of gastrointestinal movement they show promoting gastric emptying and gastrointestinal propulsion, when various pathological factors induce hyperfunction of gastrointestinal movement they show antagonism. Additionally the antioxidation and anti-inflammation of magnolol and honokiol can induce the protection on intrstinal mucosa to improve sepsis-induced gastrointestinal motility disorders, and antagonize various enteritis- and cathartics-induced diarrhea.

R285.5;R286.5