二至丸由女貞子、墨旱蓮兩味藥材組成，具有補益肝腎、滋陰止血的功效，在婦科疾病、腎病、肝病等領(lǐng)域均有廣泛的臨床應(yīng)用基礎(chǔ)?，F(xiàn)代藥理研究發(fā)現(xiàn)二至丸在保肝補腎、改善骨質(zhì)疏松、圍絕經(jīng)期綜合征、免疫調(diào)節(jié)、抗衰老、改善神經(jīng)系統(tǒng)疾病等方面具有廣泛的藥理活性，并對二至丸保護肝臟、抗骨質(zhì)疏松、抗衰老的作用機制與潛在通路開展了研究。對二至丸的藥理作用研究進展進行綜述，為進一步利用現(xiàn)代藥理學(xué)手段闡明二至丸治療肝腎陰虛證的機制、挖掘中藥經(jīng)典方“多成分、多靶點、多通路”的作用特點以及指導(dǎo)二至丸臨床應(yīng)用提供參考。

Erzhi Pill, a traditional Chinese medicinal formulation consists of Ligustri Lucidi Fructus and Ecliptae Herba, is widely used in the treatment of gynecological diseases, kidney diseases and liver diseases for the effect of tonifying liver and kidney,as well as nourishing yin and hemostasis. Extensive pharmacological activities such as liver and kidney protection, anti-osteoporosis, perimenopausal syndrome treatment, immune regulation, anti-aging, and nervous system diseases improvement were revealed by modern pharmacological research. Additionally, the mechanisms and potential pathways of Erzhi Pill in protecting liver, antiosteoporosis and anti-aging were studied. In this paper, the research progress of pharmacological effects of Erzhi Pill were comprehensively summarized to lay a foundation for further clarification of the mechanism of Erzhi Pill on liver-kidney yin deficiency syndrome by modern pharmacology, exploration of the characteristics of multi-component, multi-target and multipathway of traditional Chinese medicine, and clinical application of Erzhi Pill.

R287.5