目的 基于遙測(cè)技術(shù)建立適用于監(jiān)測(cè)清醒自由活動(dòng)狀態(tài)下巴馬小型豬心電、血壓、體溫等生理指標(biāo)的動(dòng)物模型，為其在安全藥理學(xué)研究中的應(yīng)用提供支持。方法 8只巴馬小型豬（雌雄各半）經(jīng)手術(shù)植入植入子，手術(shù)后恢復(fù)3~4周，經(jīng)體格檢查確認(rèn)已完全恢復(fù)后，采用EMKA遙測(cè)系統(tǒng)連續(xù)監(jiān)測(cè)至少24 h心電圖、血壓等生理指標(biāo)，包括心率、PR間期、QRS間期、QT間期、校正QT （QTcv）間期、體溫、收縮壓（SBP）、舒張壓（DBP）、平均動(dòng)脈壓（MBP），并于次周重復(fù)監(jiān)測(cè)1次。對(duì)巴馬小型豬的24 h指標(biāo)變化進(jìn)行分析，并與Beagle犬和食蟹猴數(shù)據(jù)進(jìn)行種屬間比對(duì)分析。結(jié)果 巴馬小型豬的心電數(shù)據(jù)和血壓數(shù)據(jù)晝夜節(jié)律均不明顯；體溫呈現(xiàn)明顯的晝夜節(jié)律，白天體溫高，夜間體溫低；動(dòng)物的心率、血壓和體溫均受外界影響比較大，與動(dòng)物的活動(dòng)呈現(xiàn)明顯的相關(guān)性；與Beagle犬和食蟹猴比較，巴馬小型豬的心率和人類最為相似，SBP僅稍高于人類。結(jié)論 通過(guò)體內(nèi)植入植入子，成功建立了巴馬小型豬植入式遙測(cè)動(dòng)物模型；與Beagle犬和食蟹猴比較，巴馬小型豬更適合用于藥物對(duì)心血管系統(tǒng)影響的評(píng)價(jià)。

Objective To establish an animal model for monitoring electrocardiogram(ECG), blood pressure(BP) and body temperature(T) of Bama miniature pig in conscious and free movement state based on telemetry technology, and to provide support for its application in safety pharmacology research.Methods Eight Bama mini-pigs(male and female half) were implanted surgically and recovered for at 3-4 weeks.ECG, blood pressure and other physiological indexes[(including heart rate, PR interval, QRS interval, QT interval, corrected QT(QTcv) interval, body temperature, systolic blood pressure(SBP), diastolic blood pressure(DBP), mean arterial pressure(MBP)] were monitored continuously by EMKA telemetry system for at least 24 hours.The monitoring was repeated in the next week.The 24 h indexes of Bama miniature pig were analyzed, and the data of Beagle dog and cynomolgus monkey were analyzed interspecies.Results The circadian rhythm of ECG and BP was not obvious in Bama miniature pig.The body temperature showed obvious circadian rhythm, which was high in daytime and low at night.The heart rate, blood pressure and body temperature of the animals were greatly influenced by the outside world, and showed obvious correlation with the activity of animals.Compared with Beagle dogs and cynomolgus monkeys, the heart rate of Bama minipigs was the most similar to that of humans, with only slightly higher systolic blood pressure, compared with that of humans.Conclusion Bama miniature pig model was successfully established by implanting seeds in Bama miniature pig, and it was proved that Bama miniature pig was more suitable for the evaluation of drug cardiovascular system than Beagle dog and cynomolgus monkey.

R965.1