代謝相關(guān)脂肪性肝?。∕AFLD）是多系統(tǒng)代謝紊亂的肝臟疾病，其發(fā)病機(jī)制的復(fù)雜性和治療目標(biāo)的多元化導(dǎo)致臨床缺乏效果理想的藥物。中藥對(duì)防治肝臟疾病有很好的療效，口服給藥是最普遍的給藥方式，藥物不僅可以通過(guò)腸道與腸道菌群建立聯(lián)系，而且經(jīng)腸道細(xì)菌作用后可改善吸收差、生物利用度低的問(wèn)題。然而，腸道微生態(tài)紊亂會(huì)導(dǎo)致機(jī)體免疫功能障礙并促進(jìn)MAFLD的發(fā)生發(fā)展。因此，口服難吸收中藥對(duì)腸道菌群的調(diào)節(jié)作用可能是治療MAFLD的潛在靶點(diǎn)。從口服難吸收中藥的藥理作用、相關(guān)代謝、腸道菌群作用等不同角度總結(jié)了中藥對(duì)MAFLD的治療作用以及腸道菌群與MAFLD的聯(lián)系，為研究中藥、MAFLD和腸道菌群間的關(guān)系提供理論依據(jù)，為進(jìn)一步研究中藥治療MAFLD奠定藥效物質(zhì)基礎(chǔ)，為從腸道菌群角度研究中藥治療MAFLD的作用機(jī)制與靶點(diǎn)奠定基礎(chǔ)。

Metabolic associated fatty liver disease(MAFLD) is a multi-systemic metabolic disorder of the liver disease. The complexity of its pathogenesis and the diversity of its therapeutic targets have led to a lack of clinically recognised and effective drugs. Traditional Chinese medicine is highly effective in the prevention and treatment of liver disease and oral administration is the most common way of drug delivery, which not only establishes contact with the gut microbiota through the gut, but also improves the poor absorption and low bioavailability through the action of gut microbiota. However, the disturbance of gut microecology can lead to immune dysfunction and promote the development of MAFLD. Therefore, the regulatory effect of orally difficult-to-absorb Chinese medicine on gut microbiota may be a potential target for the treatment of MAFLD. The therapeutic effects of traditional Chinese medicine on MAFLD and the relationship between gut microbiota and MAFLD were summarized from the perspectives of pharmacological effects and metabolism of orally difficult-to-absorb Chinese medicine and the effects of gut microbiota, providing a theoretical basis for the study of the relationship between traditional Chinese medicine, MAFLD and gut microbiota, laying the pharmacodynamic material basis for further research on the treatment of MAFLD with traditional Chinese medicine, and providing a basis for the study of the mechanism of action and targets of traditional Chinese medicine for the treatment of MAFLD from the perspective of gut microbiota.

R285.5

國(guó)家自然科學(xué)基金資助項(xiàng)目（81903933）