近年來，神經(jīng)炎癥在缺血性腦卒中中的作用引起廣泛關注，小膠質細胞、星形膠質細胞及眾多炎性因子參與了炎癥反應，并涉及到多種炎癥反應的信號通路。根據(jù)缺血性腦卒中神經(jīng)炎癥反機制可采取具有抗炎作用的藥物治療，包括非甾體類抗炎藥、抗生素類、天然植物源抗炎藥、血清蛋白酶抑制劑、他汀類、棉籽油等多種抗炎藥物。就缺血性腦卒中的神經(jīng)炎癥反應機制及相關的抗炎藥物的研究進展進行綜述，為進一步探索現(xiàn)有藥物的抗炎機制及開發(fā)新型抗炎藥物提供參考，并為缺血性腦卒中提供新的治療方向。

In recent years, the role of neuroinflammation in ischemic stroke has gained wide attention.Microglia, astrocyte, inflammatory factors and many signaling pathway are involved in the inflammatory response.According to the mechanism of ischemic stroke inflammatory reaction, anti-inflammatory drugs can be adopted for ischemic stroke medication, including nonsteroidal anti-inflammatory drug, antibiotics, natural plant-derived anti-inflammatory drugs, serum protease inhibitors, statins, cottonseed oil, et al.In this review, the present progresses of neuroinflammation mechanisms of ischemic stroke and related antiinflammatory medications are summarized.This article provides reference for the further exploring the anti-inflammatory mechanism of existing drugs and developing new anti-inflammatory drugs, as well as providing new therapeutic directions for ischemic stroke.

R965;R971

北京市醫(yī)院管理中心“青苗”計劃專項經(jīng)費資助（QMS20200811、QMS20210806）；北京市醫(yī)院管理中心“登峰”計劃專項經(jīng)費資助（DFL20190803）；首都科技領軍人才項目資助（Z191100006119017）