β-欖香烯作為腫瘤治療的輔助藥物，其注射液和口服乳劑已被廣泛用于治療包括肺癌、肝癌、腦癌、乳腺癌在內(nèi)的多種腫瘤。就β-欖香烯誘導(dǎo)腫瘤細(xì)胞凋亡、抑制腫瘤細(xì)胞遷移和侵襲、抑制腫瘤血管生長(zhǎng)、逆轉(zhuǎn)多藥耐藥和提高放化療敏感性幾方面的分子機(jī)制及其新型遞藥系統(tǒng)的開發(fā)進(jìn)行綜述，為β-欖香烯的抗腫瘤臨床應(yīng)用提供參考。

β-elemene is used as an adjuvant drug in tumor therapy, and its injections and oral emulsions have been used to treat a variety of tumors including lung cancer, liver cancer, brain cancer and breast cancer.This article reviews the molecular mechanism of β-elemene in inducing tumor cell apoptosis, inhibiting tumor cell migration and invasion, inhibiting tumor vascular growth, reversing multidrug resistance and improving chemoradiotherapy sensitivity, as well as the development of novel drug delivery systems, providing reference for the further development and clinical application of β-elemene as antitumor therapy.

R285.5;R979.1

國(guó)家自然科學(xué)基金青年資助項(xiàng)目（82104568）；天津中醫(yī)藥大學(xué)研究生科研創(chuàng)新項(xiàng)目（YJSKC-20212014）