近年來，運用秀麗隱桿線蟲模型對治療阿爾茨海默病（AD）藥物進行的研究與日俱增，通過線蟲的直觀表型及其深入的作用機制來探討中藥抗AD活性，從而實現(xiàn)藥物的初步篩選。在此基礎(chǔ)上深入研究，發(fā)現(xiàn)中藥復方六味地黃丸、提取部位銀杏葉提取物及有效成分石杉堿甲等均取得較好的臨床療效，秀麗隱桿線蟲模型對中藥資源研發(fā)具有一定的優(yōu)勢。綜述利用線蟲模型篩選的中藥復方、提取部位、有效成分及其抗AD的作用機制，為抗AD中藥新藥研發(fā)提供思路和參考。

In recent years, the advantages of Caenorhabditis elegans and transgenic models have been used to study drugs for the treatment of Alzheimer's disease(AD).Through the intuitive phenotype and in-depth mechanism of Caenorhabditis elegans, the antiAD activity of traditional Chinese medicine was discussed to realize the preliminary screening of effective drugs, the traditional Chinese medicine compound Liuwei Dihuang Pill, the extract of Ginkgo biloba leaves and the effective component huperzine A have achieved effective clinical efficacy, and the model of Caenorhabditis elegans has certain advantages in the research and development of traditional Chinese medicine resources.This paper reviews the traditional Chinese medicine compounds, extracts, active ingredients and their anti-AD mechanisms screened by the Caenorhabditis elegans model, providing ideas and references for the research and development of new anti-AD traditional Chinese medicine drugs.

R285.5;R964

國家自然科學基金資助項目（81960733）；云南省科技廳基礎(chǔ)研究面上項目（2019FB120）