目的 系統(tǒng)評價玉屏風散聯(lián)合化學藥噴霧治療支氣管哮喘的有效性及安全性。方法 計算機檢索中國學術(shù)期刊全文數(shù)據(jù)庫（CNKI）、萬方數(shù)據(jù)庫（Wanfang Data）、中國生物醫(yī)學文獻數(shù)據(jù)庫（SinoMed）、維普生物醫(yī)學數(shù)據(jù)庫（VIP）、PubMed、Cochrane Library、Embase、Web of Science數(shù)據(jù)庫中玉屏風散（顆粒）聯(lián)合化學藥噴霧治療支氣管哮喘的隨機對照試驗（RCT），檢索時限為從建庫至2022年9月1日。由2名研究人員獨立檢索、篩選文獻、提取數(shù)據(jù)、納入符合標準的文獻，參照Cochrane風險偏倚評價工具進行文獻質(zhì)量評估，使用RevMan 5.4軟件進行Meta分析。結(jié)果 共納入12項RCTs，包括1190例患者。Meta分析結(jié)果顯示，玉屏風散（顆粒）聯(lián)合化學藥噴霧（試驗組）治療支氣管哮喘的總有效率明顯優(yōu)于單純使用化學藥噴霧（對照組）［OR=3.41，95%CI（2.35，4.96），P＜0.00001］；試驗組可有效控制哮喘癥狀［MD=3.59，95%CI（2.12，5.06），P＜0.00001］，明顯改善肺功能指標［1秒用力呼氣容積（FEV1）、呼氣流量峰值（PEF）等］，F(xiàn)EV1［MD=0.57，95%CI（0.43，0.71），P＜0.0001］、PEF［MD=0.66，95%CI（0.40，0.92），P＜0.00001］。結(jié)論 玉屏風散（顆粒）聯(lián)合化學藥噴霧治療支氣管哮喘，療效顯著且安全性較高，適于臨床應用。

Objective To systematically evaluate the efficacy and safety of Yupingfeng Powder combined with chemical spray for bronchial asthma. Methods Data were electronically searched from CNKI, Wanfang Data, SinoMed, VIP, PubMed, Cochrane Library Embase, and Web of Science, from the date of establishment to September 1, 2022, for the randomized controlled trial (RCT) of Yupingfeng Powder combined with chemical spray in treatment of bronchial asthma. Two researchers dependently searched, screened, extracted data and included the documents that met the standards. The literature quality was evaluated with reference to Cochrane risk bias evaluation tool, and the data was analyzed with RevMan 5.4 software. Results A total of 12 RCTs involving 1190 patients were included. Meta-analysis showed that the total effective rate of treating bronchial asthma with Yupingfeng Powder combined with chemical spray (experimental group) was significantly better than that with conventional western medicine (control group) [OR = 3.41, 95%CI (2.35, 4.96), P<0.00001], which can effectively control asthma symptoms [MD = 3.59, 95%CI (2.12, 5.06), P<0.00001], the lung function indexes [forced expiratory volume in one second (FEV1), peak expiratory flow (PEF)] were significantly improved, FEV1 [MD = 0.57, 95%CI (0.43, 0.71), P<0.0001], PEF [MD = 0.66, 95%CI (0.40, 0.92), P<0.00001]. Conclusions Yupingfeng Powder combined with chemical spray is effective and safe for bronchial asthma, which has evidence-based basis and issuitable for clinical application.

R969.3

國家重點研發(fā)計劃（2018YFC1707503）；天津市中醫(yī)藥重點領(lǐng)域科研項目（2021010）；天津市衛(wèi)生健康委、天津市中醫(yī)藥管理局中醫(yī)中西醫(yī)結(jié)合科研課題（2021098）