[關(guān)鍵詞]
[摘要]
中藥口服制劑多為復(fù)雜體系,口感較差,影響著患者服藥的依從性,因此對其進(jìn)行口感改良具有現(xiàn)實意義。矯掩味方法多樣,其中包衣法較為常用,包衣層可減少藥物與苦味受體的接觸,從而達(dá)到掩味的目的。采用包衣法掩味時,除需保證良好的掩味效果外還需保證藥物的釋放,包衣材料的選擇至關(guān)重要。中藥制劑常用的包衣材料主要包括糖類如殼聚糖、環(huán)糊精、纖維素衍生物等,樹脂類如丙烯酸樹脂等,脂類如巴西棕櫚蠟、山崳酸甘油酯等。對常用的掩味用包衣輔料進(jìn)行了綜述,以期能為中藥掩味包衣材料的選擇提供參考。
[Key word]
[Abstract]
Most of the oral preparations of Chinese medicine are complex systems and have poor taste, which affects patients' compliance of taking medicine. Therefore, improving the taste has practical significance. There are various taste masking methods, among which, the coating method is commonly used. The coating layer can reduce the contact between the drug and the bitter receptor, so as to achieve the purpose of taste masking. When using coating method to mask taste, the release of drug should be guaranteed in addition to the good taste masking effect. Therefore, the selection of coating material is crucial. Commonly used coating materials mainly include sugars such as chitosan, cyclodextrin, cellulose derivatives, resins such as acrylic resin, and lipids such as carnauba wax and behenate glyceride. In this paper, the commonly used taste-masking coating excipients were reviewed in order to provide reference for the selection of taste-masking coating materials for chinese medicine.
[中圖分類號]
[基金項目]
山西省“四個一批”科技興醫(yī)創(chuàng)新計劃項目(2020SYS09),山西省中醫(yī)藥研究院中藥新藥研究專項(2016XYZX04)