脫氧膽酸是主要在盲腸和近端結(jié)腸由微生物作用生成的次級(jí)膽汁酸，具有一定的抗菌性和毒性。作為一種腫瘤刺激因子，脫氧膽酸可以起到誘導(dǎo)細(xì)胞凋亡、促進(jìn)癌細(xì)胞增殖的作用，參與了胃部疾病、腸道疾病、食管疾病等眾多疾病的發(fā)生與發(fā)展。就脫氧膽酸作為潛在作用靶點(diǎn)參與各種疾病的發(fā)病機(jī)制進(jìn)行綜述，以期為這些疾病的發(fā)病機(jī)制和治療藥物的研發(fā)提供思路。

Deoxycholic acid, a secondary bile acid produced mainly by microbial action in the cecum and proximal colon, which has certain antimicrobial properties and toxicity. As a tumor stimulating factor, deoxycholic acid can induce apoptosis and promote cancer cell proliferation, which was involved into the development of many diseases such as gastric diseases, intestinal diseases and esophageal diseases. Therefore, its review as a potential target in the pathogenesis of various diseases will provide ideas for the pathogenesis of diseases and drug research.

國(guó)家自然科學(xué)基金面上項(xiàng)目（82073988）