替考拉寧作為糖肽類抗菌藥，在治療革蘭陽性菌感染疾病方面發(fā)揮重要作用。但在臨床應用中，其負荷劑量不當會導致治療無效或產生不良反應，尤其對于腎功能不全及采用連續(xù)腎臟替代療法（CRRT）的患者，替考拉寧的藥動學/藥效學（PK/PD）參數(shù)發(fā)生顯著變化，且個體差異較大，干擾了臨床給藥劑量的精準，導致無法達到理想的療效。因此，通過探討替考拉寧在老年、兒童、低蛋白血癥、體外膜肺氧合（ECMO）及行不同CRRT模式的腎功能不全患者體內PK特征與療效的相關性，對替考拉寧的用藥方案進行了綜述，為臨床個體化用藥提供參考。

Teicoplanin, as a glycopeptide antimicrobial, plays an important role in the treatment of gram-positive bacteria. However, in clinical applications, improper loading dose leads to ineffective treatment or adverse reactions. Especially for patients with renal insufficiency and continuous renal replacement therapy (CRRT), the pharmacokinetics/pharmacodynamics (PK/PD) parameters of teicoplanin change significantly, and the individual differences are large, which interferes with the accuracy of clinical administration and leads to the inability to achieve the desired therapeutic effect. Therefore, by exploring the correlation between the pharmacokinetic characteristics and efficacy of teicoplanin in elderly patients, children, hypoproteinemia, extracorporeal membrane oxygenation (ECMO) and renal insufficiency patients with different CRRT modes, this article reviews the medication regimen of teicoplanin on the basis of a large number of literature and theory, so as to provide a reference for clinical individualized medication.

R969.3；R978.1

延邊大學科技計劃項目（ydkj202245）