中藥藥效物質(zhì)基礎(chǔ)研究是解釋中醫(yī)藥作用機(jī)制的基石，然而中藥復(fù)方作為一個(gè)復(fù)雜體系，作用機(jī)制與體內(nèi)效應(yīng)過程不明確等問題長(zhǎng)期桎梏中醫(yī)藥事業(yè)的發(fā)展。藥動(dòng)學(xué)-藥效學(xué)（PK-PD）相關(guān)性研究是動(dòng)態(tài)表征和定量描述活性成分與藥理作用之間相關(guān)性的有效方法，將時(shí)間、濃度和效應(yīng)結(jié)合起來(lái)，已經(jīng)成為闡明中藥藥效物質(zhì)基礎(chǔ)的技術(shù)策略，但是目前研究大都集中在結(jié)構(gòu)明確的化學(xué)藥物，缺乏符合中醫(yī)藥發(fā)展模式的相關(guān)策略。因此，非常有必要深入挖掘新的研究策略，建立符合中醫(yī)藥特色的PK-PD模型，通過進(jìn)行方法開發(fā)與技術(shù)重組，利用從化學(xué)物質(zhì)基礎(chǔ)、關(guān)鍵成分的篩選、整合PK-PD相關(guān)性的多維整合的研究思路，引入代謝組學(xué)等現(xiàn)代技術(shù)手段，全方位、及時(shí)靈敏地表征藥效特點(diǎn)，評(píng)價(jià)藥動(dòng)學(xué)考察藥物機(jī)制研究，旨在構(gòu)建更易于發(fā)現(xiàn)藥效物質(zhì)的技術(shù)體系，為闡明中藥復(fù)方的藥效物質(zhì)基礎(chǔ)提供參考。

The research on the material basis of medicinal effect of traditional Chinese medicine (TCM) is the cornerstone of explaining the mechanism of action of TCM. However, as a complex system, the development of TCM has long been hindered by the unclear mechanism and effect process in vivo. Pharmacokinetic-pharmacodynamic (PK-PD) correlation study is an effective method to dynamically characterize and quantitatively describe the correlation between active ingredients and pharmacological actions. The combination of time, concentration and effect has become a technical strategy to clarify the material basis of the efficacy of TCM. However, most of the current research focuses on chemical drugs with clear chemical composition, and lacks relevant strategies in line with the development model of TCM. Therefore, it is very necessary to deeply explore new research strategies, establish a PK-PD model that conforms to the characteristics of TCM, conduct method development and technical reorganization, use multi-dimensional integration research ideas from the basis of chemical substances, the screening of key components, and the integration of PK-PD correlation, introduce modern technical means derived from metabonomics, and comprehensively and sensitively demonstrate the evaluation of pharmacodynamic characteristics, and pharmacodynamic study of drug mechanisms. The aim is to build a technical system that is easier to find effective substances, and to provide a reference for clarifying the material basis of the efficacy of TCM prescriptions.

國(guó)家自然科學(xué)基金資助項(xiàng)目（32174099，31473415，81001688）；山西省基礎(chǔ)應(yīng)用項(xiàng)目面上項(xiàng)目（20210302123432）；名優(yōu)晉藥再開發(fā)山西省重點(diǎn)實(shí)驗(yàn)室項(xiàng)目（202104010910001）；地產(chǎn)中藥功效物質(zhì)研究與利用山西省重點(diǎn)實(shí)驗(yàn)室項(xiàng)目（202105D121009）