目的 基于網(wǎng)絡(luò)藥理學(xué)篩選治療化療所致惡心嘔吐（CINV）的潛在靶點、化合物及中藥，并分析中藥的性味歸經(jīng)以及中藥治療CINV的作用機制。方法 利用PubChem、Swiss Target Prediction平臺獲得具有致吐風(fēng)險的化療藥物靶點；基于Gene Cards、Drugbank及OMIM數(shù)據(jù)庫收集CINV疾病靶點，取“疾病-藥物”交集靶點，并通過臨床指南獲得CINV治療藥物靶點，將交集靶點及治療藥物靶點視為治療CINV的潛在靶點。通過TCMSP平臺篩選化合物和中藥。利用Cytoscape 3.7.2建立“靶點-化合物-中藥”網(wǎng)絡(luò)圖，使用網(wǎng)絡(luò)分析功能獲得重要靶點、化合物及中藥，并對中藥性味歸經(jīng)進行頻率分析。結(jié)果 獲得35個潛在靶點、799種候選化合物和395味中藥。395味中藥以苦味、辛味及溫性為主，主要分布在肝經(jīng)和肺經(jīng)中，其次是脾經(jīng)及胃經(jīng)。結(jié)論 運用中藥治療CINV具有廣闊的發(fā)展空間，該研究為CINV的中藥治療及新藥的開發(fā)提供了思路及理論依據(jù)。

Objective To screen potential targets, compounds and traditional Chinese medicines (TCM) for treatment of chemotherapy-induced nausea and vomiting (CINV) based on network pharmacology, and to analyse the nature and taste of TCM and mechanisms of action of TCM in treatment of CINV. Methods PubChem and Swiss Target Prediction platform were used to obtain chemotherapeutic drug targets with risk of emesis. Gene Cards, Drugbank and OMIM database were used to collect CINV disease targets, and to obtain "disease-drug" intersection targets. And through clinical guidelines, and intersecting targets and therapeutic drug targets were considered as potential targets for treatment of CINV. Compounds and TCM were screened through TCMSP platform. Cytoscape 3.7.2 was used to build a "target-compound-Chinese medicine" network diagram, and the network analysis function was used to obtain the important targets, compounds and TCM, and frequency analysis of flavor and ascription of TCM were conducted. Results 35 potential targets, 799 candidate compounds and 395 TCM were obtained. 395 herbal medicines are mainly bitter, acrid and warm, mainly distributed in the liver and lung meridians, followed by the spleen and stomach meridians. Conclusion The use of TCM in treatment of CINV has a broad scope for development, and this study provides ideas and theoretical basis for the development of TCM treatment and new drugs for CINV.

全國名老中醫(yī)藥專家傳承工作室建設(shè)項目（國中醫(yī)藥人教發(fā)［2016］42號）；第六批全國老中醫(yī)藥專家學(xué)術(shù)經(jīng)驗繼承工作項目（國中醫(yī)藥人教發(fā)［2017］29號）