目的 探究固液萃取法和氣固萃取法對加載揮發(fā)油多孔材料釋放情況評價的差異。方法 以加載薄荷油的沸石分子篩為例，以薄荷腦為指標性成分，建立其液體進樣及頂空進樣氣相檢測方法，分別以固液萃取法和氣固萃取法評價其釋放性能，并比較兩種方法對加載揮發(fā)油多孔材料釋放情況評價的差異。結果 固液萃取法測得載藥沸石中薄荷油在0～2.5 h不斷釋放，在2.5 h釋放率達到69.29%；氣固萃取法測得薄荷油在0～30 min的釋放曲線可反映其釋放情況，其釋放速率逐漸降低，在60 min時趨于飽和。結論 固液萃取法可測得各個時間點的載藥多孔材料揮發(fā)油含量，獲取載藥量并換算釋放量，且釋放條件可根據(jù)測定需求調(diào)整。氣固萃取法可在飽和量以內(nèi)用于不同類型載藥多孔材料釋放性能比較。

Objective To explore the difference of evaluation of the release of porous materials loaded with volatile oil by solidliquid extraction and gas-solid extraction. Methods In this study, the zeolite molecular sieve loaded with menthol oil was taken as an example and menthol was used as the index component to establish the detection methods of liquid injection and headspace injection gas phase. The solid-liquid extraction method and gas-solid extraction method were used to evaluate the release properties of the porous materials loaded with volatile oil, and the differences between the two methods were compared. Results The oil of menthol in zeolite was released continuously from 0 to 2.5 h by solid-liquid extraction method, and the release rate reached 69.29%. The release curve of peppermint oil measured by gas-solid extraction method can reflect the release of peppermint oil in 0—30 min, and the release rate decreases gradually and tends to saturation at 60 min. The method should be carried out within the saturation of headspace bottle. Conclusion The volatile oil content of drug-loaded porous material can be measured by solid-liquid extraction method at each time point, the drug-loaded amount can be obtained and the release amount can be converted, and the release condition can be adjusted according to the determination requirements. The gas-solid extraction method can be used to compare the release properties of different drug-loaded porous materials under saturation.

R927.2

國家自然科學基金面上項目（8217141690）