[關(guān)鍵詞]
[摘要]
目的 分析新型冠狀病毒肺炎(COVID-19)住院患者阿茲夫定片的使用合理性及不良事件發(fā)生情況,為臨床合理用藥提供參考。方法 采用回顧性研究方法,對(duì)襄陽(yáng)市中心醫(yī)院2022年11月1日—2022年12月31日因COVID-19住院且使用阿茲夫定片的患者進(jìn)行全樣本點(diǎn)評(píng),從藥物適應(yīng)證、用法用量、給藥時(shí)機(jī)、用藥療程、聯(lián)合用藥等方面評(píng)價(jià)用藥合理性,同時(shí)考察用藥后不良事件發(fā)生率,評(píng)估用藥安全性。結(jié)果 使用阿茲夫定片的患者共計(jì)284例,其中122例用藥不合理,不合理率42.96%。不合理用藥共發(fā)生179例次,適應(yīng)證不適宜74例次(26.06%),用法用量不適宜70例次(24.65%),聯(lián)合用藥不適宜24例次(8.45%)。使用阿茲夫定片患者中77例(27.11%)在用藥后共發(fā)生151項(xiàng)不良事件,其中血小板計(jì)數(shù)改變、乳酸升高、總膽汁酸升高及胃腸不適最常見(jiàn)。點(diǎn)評(píng)結(jié)果為“不合理”的病例不良事件發(fā)生率(35.25%)顯著高于點(diǎn)評(píng)結(jié)果為“合理”的病例(20.99%)。結(jié)論 阿茲夫定片臨床用藥存在不合理情況,且不合理用藥與患者住院期間不良事件的發(fā)生密切相關(guān),臨床應(yīng)用時(shí)應(yīng)加強(qiáng)監(jiān)管和干預(yù),促進(jìn)臨床合理用藥,保障患者用藥安全。
[Key word]
[Abstract]
Objective To analyze the clinical application rationality and adverse reactions of Azvudine Tablets in hospitalized patients with COVID-19 and to provide references for the rational drug use. Methods Data of the cases using Azvudine Tablets in Xiangyang Central Hospital from November 1, 2022 to December 31, 2022 were retrospectively collected and analyzed, in terms of indication, dosage and usage, medication timing, medication course, and combination of drugs. At the same time, the incidence of adverse reactions after drug use were investigated, in order to evaluate medication safety. Results There were a total of 284 cases using Azvudine Tablets among which 122 cases used unreasonably, with an unreasonable rate of 42.96%. There were totally 179 cases of unreasonable use of Azvudine Tablets including 74 cases (26.06%) of inappropriate indications, 70 cases (24.65%) of improper usage and dosage, and 24 cases (8.45%) of improper combination. A total of 151 adverse reactions occurred after Azvudine Tablets treatment for 77 patients (27.11%), of which platelet count change, lactic acid increase, total bile acid increase and gastrointestinal discomfort were the most common. And the incidence of adverse reactions (35.25%) of cases with "unreasonable" results was significantly higher than that with "reasonable" results (20.99%). Conclusion There were unreasonable use of Azvudine Tablets in clinic, which were closely related to the occurrence of adverse reactions, and need to be intervened in order to promote rational drug use and ensure drug safety of patients.
[中圖分類號(hào)]
R978.7
[基金項(xiàng)目]
湖北省衛(wèi)健委2018—2019年中醫(yī)藥科研項(xiàng)目(青年人才項(xiàng)目)(ZY2019Q013);襄陽(yáng)市2021年度醫(yī)療衛(wèi)生領(lǐng)域科技計(jì)劃項(xiàng)目(2021ZD05)