目的 系統(tǒng)評價耐甲氧西林金黃色葡萄球菌（MRSA）血流感染危險因素，為各級醫(yī)療機(jī)構(gòu)預(yù)防MRSA血流感染提供依據(jù)。方法 計算機(jī)檢索中國學(xué)術(shù)期刊全文數(shù)據(jù)庫（CNKI）、萬方數(shù)據(jù)庫（Wanfang Data）、維普中文期刊全文數(shù)據(jù)庫（VIP）、中國生物醫(yī)學(xué)文獻(xiàn)數(shù)據(jù)庫（CBM）、PubMed、Embase等數(shù)據(jù)庫，檢索時限為建庫至2023年6月6日，收集國內(nèi)外MRSA血流感染危險因素的病例對照研究，采用RevMan 5.3軟件進(jìn)行Meta分析。結(jié)果 共納入16篇病例對照研究，涉及感染危險因素49個。結(jié)果顯示年齡（年齡≥65、60歲），醫(yī)院感染，合并腦梗死、慢性肝膽疾病、消化性潰瘍、感染性休克、肺部感染，中心靜脈置管、留置導(dǎo)尿管、氣管插管，入住ICU，感染前使用碳青霉烯類、糖肽類、第3代頭孢菌素類，感染來源于呼吸道、皮膚軟組織、腹腔、導(dǎo)管、感染來源大于2個部位，住院時間，MRSA血流感染組與甲氧西林敏感金黃色葡萄球菌（MSSA）血流感染組相比，差異有統(tǒng)計學(xué)意義（P<0.05）。結(jié)論 MRSA血流感染危險因素多，臨床診療活動中應(yīng)重視患者基礎(chǔ)疾病，規(guī)范化進(jìn)行侵入性操作，重視病區(qū)環(huán)境的消殺和醫(yī)務(wù)人員手衛(wèi)生，合理使用抗菌藥物，動態(tài)評估患者生命體征，根據(jù)危險因素制定感控策略，從而降低MRSA血流感染發(fā)生率。

Objective To systematically evaluate the risk factors of bloodstream infection caused by methicillin-resistant Staphylococcus aureus (MRSA), and to provide evidence for medical institutions at all levels to prevent MRSA bloodstream infection. Methods The databases of CNKI, Wanfang Data, VIP, CBM, PubMed, and Embase were searched by computer. The retrieval time limit was from the establishment of the database to June 6, 2023. Case-control study on risk factors of MRSA bloodstream infection at home and abroad were collected, and Meta-analysis was performed by RevMan 5.3 software. Results A total of 16 case-control studies were included, involving 49 risk factors of infection. The results showed that age, age ≥ 65, age ≥ 60 years old, hospital infection, cerebral infarction, chronic hepatobiliary disease, peptic ulcer, septic shock, pulmonary infection, central vein catheterization, foley catheter, tracheal intubation, admission to ICU, carbapenem, glycopeptides, third-generation cephalosporin before infection, infection from respiratory tract, skin and soft tissue, abdominal cavity, catheter, infection from more than two parts, hospital stay, the difference between the MRSA bloodstream infection group and the methicillin-sensitiv Staphylococcus aureus (MSSA) bloodstream infection group was statistically significant (P< 0.05). Conclusion There are many risk factors for MRSA bloodstream infection. In clinical diagnosis and treatment activities, should pay attention to patients' basic diseases, standardize invasive operations, pay attention to the disinfection and sterilization of the ward environment and the hand hygiene of medical personnel, use antibiotics reasonably, dynamically assess patients' vital signs, and formulate sensing and control strategies based on risk factors, so as to reduce the incidence of MRSA bloodstream infection.

四川省醫(yī)院協(xié)會2022年青年藥師科研專項(xiàng)資金項(xiàng)目（22045）；四川省醫(yī)學(xué)會（恒瑞）科研基金專項(xiàng)科研課題（2021HR26）；2022年度成都醫(yī)學(xué)院科學(xué)研究機(jī)構(gòu)開放課題和校級科研項(xiàng)目（2022LHNBZYB-11）；南充市科技計劃項(xiàng)目（22YFZJZC0047）