目的 通過可視化圖譜客觀、定量分析參附注射液的研究現(xiàn)狀和熱點方向，為今后深入研究和臨床應用提供指導。方法 分別檢索中國學術(shù)期刊全文數(shù)據(jù)庫（CNKI）、維普中文期刊服務平臺（VIP）、萬方數(shù)據(jù)庫（Wanfang Data）和Web ofScience核心合集從建庫至2023年5月6日收錄的參附注射液研究文獻，采用人工閱讀的方法完成文獻數(shù)據(jù)除重和篩選，使用CiteSpace軟件對研究國家、機構(gòu)和作者合作情況系統(tǒng)分析，繪成關(guān)鍵詞共現(xiàn)圖、聚類圖和突現(xiàn)性分析圖。結(jié)果 經(jīng)刪選后納入中文文獻3 456篇、英文文獻159篇，年發(fā)文量均呈波動型。中國為頻數(shù)最大且中心性最高的國家。對中文文獻分析發(fā)現(xiàn)：武漢大學人民醫(yī)院是頻數(shù)最高的機構(gòu)；李春盛是發(fā)文量最多的作者；頻數(shù)最高的關(guān)鍵詞為“心力衰竭”；中心性最大的關(guān)鍵詞是“臨床療效”；產(chǎn)生了10個聚類，大致分為5個方面；突現(xiàn)詞有15個，其中“膿毒癥”的突現(xiàn)性最高。對英文文獻分析發(fā)現(xiàn)：Capital Med Univ（首都醫(yī)科大學）是頻數(shù)最大、中心性最高的機構(gòu)；Li Chunsheng（李春盛）是發(fā)文量最多的作者；Shenfu Injection（參附注射液）是頻數(shù)最大、中心性最高的關(guān)鍵詞；生成了8個聚類；突現(xiàn)詞有17個，其中cardiac arrest（心臟驟停）突現(xiàn)性最高。結(jié)論 參附注射液主要適應證為心力衰竭、膿毒癥、心臟驟停和重癥肺炎等，主要藥理作用為抗炎、抗凋亡、改善氧化應激和免疫功能等，主要研究方法為臨床隨機對照試驗和大小鼠動物實驗等。

Objective To objectively and quantitatively analyze the research status and hot spots of Shenfu Injection by visual atlas, and to provide guidance for further research and clinical application in the future. Methods The literature on Shenfu Injection included in the Chinese and English databases from CNKI, VIP, Wanfang Data and Web of Science core collection from its establishment to May 6, 2023 were searched respectively. Manual reading was used to complete the reclassification and screening of literature data. CiteSpace software was used to systematically analyze the cooperation between research countries, institutions and authors, and draw keywords co-occurrence map, cluster map and emergence analysis map. Results After deletion, 3 456 Chinese and 159 English literatures were included, and the annual number of publications fluctuated. China is the country with the largest frequency and highest centrality. The analysis of Chinese literature showed that the People's Hospital of Wuhan University was the most frequent institution. Li Chunsheng was the author with the most publications. The keyword with the highest frequency was "heart failure". The key word with the greatest centrality was "clinical effect". Ten clusters were generated, which could be roughly divided into five aspects. There were 15 emergent words, among which "sepsis" was the most emergent. The analysis of English literature showed that Capital Med Univ was the institution with the highest frequency and the highest centrality. Li Chunsheng was the author who published the most articles. Shenfu Injection was the key word with the highest frequency and centrality. Eight clusters were generated. There were 17 sudden words, and cardiac arrest had the highest sudden expression. Conclusion The main adaptive diseases of Shenfu Injection were heart failure, sepsis, cardiac arrest and severe pneumonia, etc. The main pharmacological effects of Shenfu Injection were anti-inflammatory, anti-apoptosis, improvement of oxidative stress and immune function, etc. The main research methods were randomized controlled clinical trials and animal experiments in rats and mice.

R972

國家自然科學基金資助項目（82274412）；廣東省重點領(lǐng)域研發(fā)項目（2020B1111100001）；湖南省自然科學基金資助項目（2020JJ4062，2020JJ5408）。