白藜蘆醇是天然化合物，屬于非黃酮類的多酚化合物，存在于多種植物中，表現(xiàn)出良好的抗肺癌作用。白藜蘆醇可以通過(guò)阻滯細(xì)胞周期、調(diào)控基因表達(dá)、抑制無(wú)氧糖酵解和干擾相關(guān)信號(hào)通路轉(zhuǎn)導(dǎo)等方面抑制腫瘤細(xì)胞增殖；通過(guò)下調(diào)金屬蛋白酶（ADAM）、基質(zhì)金屬蛋白酶（MMP）等抑制腫瘤細(xì)胞侵襲和遷移、通過(guò)下調(diào)血管內(nèi)皮生成因子（VEGF）抗腫瘤血管生成、通過(guò)激活死亡受體途徑和線粒體受體途徑誘導(dǎo)腫瘤細(xì)胞凋亡和自噬、通過(guò)抑制耐藥基因逆轉(zhuǎn)靶向藥物耐藥和增強(qiáng)化療藥物敏感性而發(fā)揮抗肺癌活性。系統(tǒng)梳理了國(guó)內(nèi)外有關(guān)白藜蘆醇抗肺癌藥理作用及其機(jī)制的研究進(jìn)展，為抗肺癌新藥研發(fā)提供參考。

Resveratrol is a natural compound, which belongs to the non flavonoid polyphenol compound. It exists in a variety of plants and shows a good anti lung cancer effect. Resveratrol can inhibit the proliferation of tumor cells by blocking cell cycle, regulating gene expression, inhibiting anaerobic glycolysis and interfering with related signal pathway transduction. It can inhibit tumor cell invasion and migration by down-regulation of metalloproteinases (ADAM), matrix metalloproteinase (MMP), etc. Resveratrol can inhibit tumor angiogenesis by down-regulation of vascular endothelial growth factor (VEGF). It can induce the tumor cell apoptosis and autophagy by activation of death receptor pathway and mitochondrial receptor pathway. It can reverse targeted drug resistance by inhibition of drug resistance genes, and enhance chemotherapy drug sensitivity. This article systematically reviewed the research progress of resveratrol's pharmacological action and mechanism against lung cancer at home and abroad, providing a reference for the development of new drug development against lung cancer.

R285.5

國(guó)家中醫(yī)藥管理局中醫(yī)藥傳承創(chuàng)新團(tuán)隊(duì)資助項(xiàng)目（ZYYCXTD-C-202205）；中國(guó)中醫(yī)藥循證醫(yī)學(xué)中心“業(yè)務(wù)研究室主任專項(xiàng)”