全切片圖像是通過數(shù)字切片掃描儀將整個(gè)組織切片掃描生成的二維圖像，近年來已廣泛應(yīng)用于病理學(xué)教學(xué)、組織切片討論、科研等領(lǐng)域。參照美國毒性病理學(xué)會(huì)（STP）對(duì)全切片圖像在診斷中的應(yīng)用建議、經(jīng)濟(jì)合作與發(fā)展組織（OECD）和美國食品藥品管理局（FDA）關(guān)于使用全切片圖像進(jìn)行病理學(xué)同行評(píng)議的指導(dǎo)原則，對(duì)藥物非臨床研究質(zhì)量管理規(guī)范（GLP）條件下應(yīng)用全切片圖像進(jìn)行毒性病理學(xué)同行評(píng)議的工作流程、內(nèi)容和要求進(jìn)行相關(guān)總結(jié)。同時(shí)結(jié)合中國合同研究組織（CRO）采用全切片圖像開展毒性病理學(xué)評(píng)價(jià)進(jìn)行概述，以期提升我國毒性病理學(xué)評(píng)價(jià)和病理學(xué)同行評(píng)議工作的規(guī)范性與專業(yè)水平。

Whole slide images (WSI) are a type of two-dimensional image generated by scanning the entire tissue slides with a digital scanner, which have been widely used in various fields in pathology, including teaching, tissue slide discussion and scientific research in recent years. According to the recommendation of the Society of Toxicologic Pathology (STP) on the application of WSI in diagnosis and the guidance of Organization for Economic Co-operation and Development (OECD) and US Food and Drug Administration (FDA) on WSI use for peer review of toxicologic pathology, this article summarized the procedures, contents, and requirements of WSI peer review under Good Laboratory Practice (GLP) conditions. In addition, it provided an overview of toxicologic pathology evaluation using WSI carried out by contract research organizations (CROs) in China, as an attempt to advance the standardization and professionalism of toxicologic pathology evaluation and pathology peer review in China.

R965.3