目的 通過對國家中藥復(fù)方專利治療潰瘍性結(jié)腸炎的系統(tǒng)分析，總結(jié)歸納其配伍規(guī)律及用藥發(fā)展趨勢。方法 檢索國家知識產(chǎn)權(quán)局中國專利公布網(wǎng)站中治療潰瘍性結(jié)腸炎的中藥復(fù)方專利數(shù)據(jù)。采用SPSS Statistic 26.0和SPSS Modeler 15.0對高頻中藥（頻次≥20）進(jìn)行性味歸經(jīng)、功效分析，以及系統(tǒng)聚類、Apriori關(guān)聯(lián)規(guī)則與網(wǎng)絡(luò)分析。以Cytoscape3.7.2構(gòu)建少見中藥高度互聯(lián)的子網(wǎng)絡(luò)，挖掘新的藥物組合。結(jié)果 納入從建庫至2023年8月31日治療潰瘍性結(jié)腸炎的中藥復(fù)方專利共147項(xiàng)，涉及中藥500味，高頻中藥20味，有甘草（60次，40.82%）、黃連（56次，38.10%）、黃芪（46次，31.29%）等，藥味以苦味最常見，藥性以寒、溫為主，多歸脾經(jīng)。以清熱藥和補(bǔ)益藥居多。聚類分析得到4組中藥組合（新處方），主要有“黃連、木香、白芍、當(dāng)歸、甘草、陳皮、黃芩、柴胡、茯苓、薏苡仁”等。常用藥對有木香-黃連（支持度21.77%，置信度71.88%）等，常用角藥組合有白芍-黃連-甘草（支持度14.97%，置信度72.73%）等。挖掘的潛在處方有“假茼蒿-建蘭根-橘餅-橘紅珠-紅娘子-還陽參”等。結(jié)論 國家中藥復(fù)方專利治療潰瘍性結(jié)腸炎常用清熱解毒藥和益氣健脾藥等，符合潰瘍性結(jié)腸炎的臨床治療原則。難治性或重度潰瘍性結(jié)腸炎可考慮攻補(bǔ)兼施之法，適當(dāng)加入活血化瘀的蟲類藥。

Objective To summarize and summarize the rules of compounding and the development trend of medication through systematic analysis of national Chinese medicine compounding patents for the treatment of ulcerative colitis. Methods The data of Chinese herbal compound patents for the treatment of ulcerative colitis were retrieved from the Chinese patent publication website of the State Intellectual Property Office. SPSS Statistic 26.0 and SPSS Modeler 15.0 were used to analyze high-frequency traditional Chinese medicines (frequency ≥ 20) for sexual flavor, attribution and efficacy, as well as systematic clustering, Apriori association rules and network analysis. Cytoscape 3.7.2 was used to construct the core complex network of traditional Chinese medicine. Constructing a highly interconnected subnetwork of rare Chinese medicinal herbs using Cytoscape 3.7.2 to unveil novel drug combinations. Results A total of 147 herbal compound patents for the treatment of ulcerative colitis were included from the establishment of the database to August 31, 2023, involving 500 herbal medicines and 20 high-frequency herbal medicines, including Glycyrrhizae Radix et Rhizoma (60 times, 40.82%), Coptidis Rhizoma (56 times, 38.10%) and Astragali Radix (46 times, 31.29%), with bitter taste being the most common and cold and warm properties, mostly attributed to the spleen meridian. Heatclearing drugs and tonic drugs were mostly used. Cluster analysis yielded four groups of herbal combinations (new prescriptions), mainly "Coptidis Rhizoma, Aucklandiae Radix, Paeoniae Radix Alba, Angelicae Sinensis Radix, Glycyrrhizae Radix et Rhizoma, Citri Reticulatae Pericarpium, Scutellariae Radix, Bupleuri Radix, Poria and Coicis Semen". Commonly used pairs include Aucklandiae Radix-Coptidis Rhizoma (support 21.77%, confidence 71.88%), etc. Commonly used corner drug combinations include Paeoniae Radix Alba-Coptidis Rhizoma-Glycyrrhizae Radix et Rhizoma (support 14.97%, confidence 72.73%), etc. The potential prescriptions were "Eclipta prostrata-Dendrobium nobile-Citrus aurantium-Citrus reticulata-Epimedium brevicornum", etc. Conclusion The treatment of ulcerative colitis with national herbal compound patent is commonly used to clear heat and detoxify the toxins and benefit the qi and spleen, which is in line with the clinical treatment principle of ulcerative colitis. Refractory or severe ulcerative colitis can be considered as a combination of attacking and tonifying method, with appropriate addition of worm-like drugs that activate blood circulation and remove blood stasis.

R285.5

云南省中醫(yī)藥應(yīng)用基礎(chǔ)研究聯(lián)合專項(xiàng)-面上項(xiàng)目（202101AZ070001-268）；昆明市衛(wèi)生健康委員會衛(wèi)生科研課題（2022-04-01-009）；昆明市衛(wèi)生科技人才培養(yǎng)項(xiàng)目暨“十百千”工程［2022-SW（后備）-60］