缺血性腦卒中（IS）和阿爾茨海默?。ˋD）具有共同的病理特征，如β-淀粉樣蛋白沉積、血管病變、氧化應(yīng)激和神經(jīng)炎癥等，均會(huì)導(dǎo)致認(rèn)知能力下降。髓樣細(xì)胞觸發(fā)受體2（TREM2）作為免疫相關(guān)受體，可以通過調(diào)節(jié)小膠質(zhì)細(xì)胞的表型和功能來協(xié)調(diào)神經(jīng)炎癥，參與AD和IS的進(jìn)程。蛇床子素、補(bǔ)脾醒神益智方、AL002、褪黑激素、羥基紅花黃色素A等靶向TREM2免疫受體，對AD和IS等神經(jīng)退行性疾病有療效。就TREM2在AD和IS中的重要作用和以TREM2為靶點(diǎn)治療AD和IS的相關(guān)藥物進(jìn)行綜述，以期為退行性疾病、腦血管疾病等相關(guān)治療藥物的研發(fā)提供新思路。

Alzheimer's disease (AD) and Ischemic stroke (IS) have common pathological features, such as Aβ deposition, vascular lesions, oxidative stress and neuroinflammation, which can lead to cognitive decline. Triggering receptor expressed on myeloid cells 2 (TREM2), as an immune-related receptor, can coordinate neuroinflammation and participate in the process of AD and IS by regulating the phenotype and function of microglia. At present, many drugs, such as osthole, Bupi Xingshen Yizhi recipe, AL002, melatonin, hydroxysafflor yellow A, etc., target TREM2 immune receptors and have therapeutic effects on neurodegenerative diseases such as AD and IS. In this paper, the important role of TREM2 in AD and IS and the related drugs targeting TREM2 to treat AD and IS are reviewed, so as to provide new ideas for the research and development of related drugs such as degenerative diseases and cerebrovascular diseases.

天津市科學(xué)基金項(xiàng)目（21JCYBJC01260）