烏藥為樟科山胡椒屬植物烏藥Lindera aggregata（Sims）Kosterm.的干燥塊根，主要成分包括倍半萜類、生物堿類、黃酮類和揮發(fā)油等，具有抗氧化、抑菌、抗炎鎮(zhèn)痛、抗腫瘤等多種藥理作用。近年，諸多研究表明烏藥對(duì)酒精性肝損傷、化學(xué)性肝損傷、免疫性肝損傷、糖尿病合并肝損傷、脂肪肝、肝癌等肝臟相關(guān)疾病都有防治作用。綜述了烏藥水提取物、醇提取物、醇提取物的萃取物、葉提取物、根揮發(fā)油及烏藥醚內(nèi)酯抗肝損傷的藥理作用及研究現(xiàn)狀，以期為后續(xù)烏藥相關(guān)保肝藥物的開發(fā)及利用提供理論基礎(chǔ)。

Lindera aggregata was the dried root tubers of Lindera aggregata（Sims）Kosterm. The main components include sesquiterpenoids, alkaloids, flavonoids and volatile oils, which have various pharmacological effects such as antioxidant, antibacterial, anti-inflammatory and analgesic, and anti-tumour. In recent years, many studies have shown that Lindera aggregata has been effective against alcoholic liver injury, chemical liver injury, immune liver injury, diabetes combined with liver injury, fatty liver, liver cancer and other liver-related diseases. This article reviewed the pharmacological effects on liver injury and research status of water extract, alcohol extract, various extracts of alcohol extract, leaf extract, volatile oil of Lindera aggregata and linderane, providing a theoretical basis for the subsequent development and utilization of Lindera aggregata related drugs.

R285.5

湖南省自然科學(xué)基金資助項(xiàng)目（2020JJ5434）；湖南省衛(wèi)生健康委科研項(xiàng)目（C202313057956，D202302048806）；湖南中醫(yī)藥大學(xué)校級(jí)科研基金（2019XJJJ033，2021XJJJ040，2022XYLH004）；湖南省“十四五”中醫(yī)重點(diǎn)?？疲褐兴帉W(xué)資助項(xiàng)目（湘中醫(yī)藥函［2023］4號(hào)）