去氫吳茱萸堿是吳茱萸的主要活性成分之一，作為吲哚喹唑酮類(lèi)生物堿，其藥理作用包括抗腫瘤、抗心律失常、抗炎、抗病毒等，尤其抗阿爾茨海默病作用顯著。去氫吳茱萸堿易透過(guò)血腦屏障發(fā)揮中樞神經(jīng)作用，其藥時(shí)曲線(xiàn)呈現(xiàn)雙峰，在體內(nèi)發(fā)生羥基化、去甲基化、與葡萄糖醛酸結(jié)合等代謝反應(yīng)。對(duì)去氫吳茱萸堿單體及其在吳茱萸和制劑中的吸收、分布、代謝與排泄過(guò)程等藥動(dòng)學(xué)研究進(jìn)展進(jìn)行綜述，總結(jié)其藥動(dòng)學(xué)特征，以期為臨床應(yīng)用及新藥研發(fā)提供參考。

Dehydroevodiamine is a main active ingredient from Euodia rutaecarpa. As an indoline-quinazolone alkaloid, its pharmacological effects include anti-tumor, anti-arrhythmia, anti-inflammatory, antiviral, especially in anti-Alzheimer's disease. Dehydroevodiamine could easily cross the blood-brain barrier and act on central nervous system. Its drug time curve showed a bimodal phenomenon, and metabolic pathways are summarized such as hydroxylation, demethylation and conjugation with glucuronic acid. The pharmacokinetics research progress on absorption, distribution, metabolism and excretion of dehydroevodiamine, and dehydroevodiamine in Euodia rutaecarpa and its preparations, were reviewed, and the pharmacokinetic characteristics were summarized, so as to provide reference for the clinical application, further development and application of dehydroevodiamine.

R969.1

黑龍江省省屬高?；究蒲袠I(yè)務(wù)費(fèi)資助項(xiàng)目（1452MSYQN008）；牡丹江師范學(xué)院資助項(xiàng)目（MNUQN202304）