目的 對(duì)甘草干姜湯在古代中醫(yī)典籍和現(xiàn)代中醫(yī)臨床處方中的組方用藥配伍規(guī)律進(jìn)行分析并比較其異同。方法 分別從《中醫(yī)方劑大辭典》和河南中醫(yī)藥大學(xué)第一附屬醫(yī)院 2017—2019 年醫(yī)生開(kāi)具的住院處方中，篩選含有甘草-干姜、炙甘草-干姜、甘草-炮姜或炙甘草-炮姜藥對(duì)的所有方劑，組方統(tǒng)一標(biāo)準(zhǔn)化后，運(yùn)用 SPSS v18.0 和 Cytoscape 等軟件，對(duì)提取的數(shù)據(jù)進(jìn)行用藥頻次、劑量、配伍比例、疾病科屬等統(tǒng)計(jì)和比較分析。結(jié)果 分別從《中醫(yī)方劑大辭典》和臨床處方中篩選出2743 首和 24354 首符合要求的組方，其中含炙甘草-干姜的方劑出現(xiàn)頻次最多，分別占比 59.8% 和 48.0%；且在篩選所得的組方中，以 1∶1 配比出現(xiàn)的頻次最高?！吨嗅t(yī)方劑大辭典》中含有甘草-干姜、炙甘草-干姜所治疾病科屬以脾胃病為主，甘草-炮姜和炙甘草-炮姜所治疾病科屬以婦科病為主；現(xiàn)代中醫(yī)臨床處方中，甘草-干姜、甘草-炮姜和炙甘草-干姜所治疾病科屬以脾胃肝膽科為主，炙甘草-炮姜所治疾病科屬以產(chǎn)科為主。結(jié)論 甘草干姜湯古今應(yīng)用以炙甘草-干姜 1∶1 配比最為常用，所治疾病以脾胃病為主，為該藥對(duì)的現(xiàn)代臨床應(yīng)用及科學(xué)研究的開(kāi)展提供依據(jù)。

Objective To analyze and compare the similarities and differences in the pattern of grouping and medication dispensing of Licorice and Dried Ginger Decoction in ancient Chinese medicine dictionaries and modern Chinese medicine clinical prescriptions. Methods From the Dictionary of Traditional Chinese Medicine Formulas and the inpatient prescriptions issued by doctors of First Affiliated Hospital of Henan University of Chinese Medicine from 2017 to 2019, respectively, all formulas containing licorice-dried ginger, prepared licorice-dried ginger, licorice-canned ginger, or prepared licorice-canned ginger pairs were screened, and the groupings were standardized uniformly, and software such as SPSS v18.0 and Cytoscape were applied. The extracted data were statistically and comparatively analyzed in terms of frequency of medication, dosage, proportion of compounding, and disease family. Results 2743 and 24 354 formulas were screened from the Dictionary of Traditional Chinese Medicine Formulas and clinical prescriptions, respectively. Among them, formulas containing prepared licorice and dried ginger, which accounted for 59.8% and 48.0% of the total number of formulas respectively, appeared most frequently, and among the formulas obtained from the screening, the frequency of the 1∶ 1 ratio was the highest. In the Dictionary of Chinese Medicine Formulas, the disease families treated by licorice-dried ginger, prepared licorice-dried ginger were mainly spleen and stomach diseases, and the disease families treated by licorice-canned ginger and prepared licorice-canned ginger were mainly gynecological diseases; in the clinical prescriptions of modern Chinese medicine, the disease families treated by licorice-dried ginger, licoricecanned ginger and prepared licorice-dried ginger were mainly spleen, stomach, liver, and gallbladder diseases, and the disease families treated by prepared licorice-canned ginger were mainly obstetrics and gynaecology diseases. Conclusion The ancient and modern applications of Licorice and Dried Ginger Decoction are most commonly used in the ratio of 1∶1 of prepared licorice-dried ginger, and the diseases treated are mainly in the spleen and stomach, and this study can provide a basis for the modern clinical application of this medicinal pair and the development of scientific research.

R289

2022 年度河南省中醫(yī)藥科學(xué)研究專項(xiàng)課題（2022ZY2010）；河南省高?？萍紕?chuàng)新團(tuán)隊(duì)（23IRTSTHN026）；河南省中醫(yī)藥拔尖人才培養(yǎng)項(xiàng)目（豫中醫(yī)科教［2018］35 號(hào)）；河南中醫(yī)藥大學(xué) 2023 年度研究生科研創(chuàng)新能力提升計(jì)劃（2023KYCX010）