淫羊藿苷是補(bǔ)腎類中藥淫羊藿的主要活性成分，屬異戊烯基黃酮醇類化合物，具有免疫調(diào)節(jié)、抗炎、抗氧化應(yīng)激、抗腫瘤、抗衰老和抗骨質(zhì)疏松等多種藥理活性，對(duì)神經(jīng)、免疫、腫瘤、內(nèi)分泌、心腦血管和肌肉骨骼系統(tǒng)等疾病均具有良好的功效，尤其對(duì)骨骼系統(tǒng)疾病具有多通道、多靶點(diǎn)的活性作用，在關(guān)節(jié)軟骨損傷性疾病中具有潛在應(yīng)用優(yōu)勢(shì)。淫羊藿苷可通過(guò)促進(jìn)軟骨細(xì)胞增殖分化及抑制過(guò)度凋亡、減少炎癥因子釋放、抑制軟骨下骨結(jié)構(gòu)重塑、促進(jìn)關(guān)節(jié)軟骨細(xì)胞外基質(zhì)合成、促進(jìn)骨髓間充質(zhì)干細(xì)胞遷移和成軟骨分化等多種作用機(jī)制來(lái)促進(jìn)關(guān)節(jié)軟骨損傷修復(fù)。對(duì)淫羊藿苷在治療關(guān)節(jié)軟骨損傷疾病中發(fā)揮不同修復(fù)作用及其機(jī)制進(jìn)行綜述，以期為深入研究和相關(guān)藥物研發(fā)提供參考依據(jù)。

Icariin is the main active monomer of the kidney tonic Chinese medicine Epimedii Folium, belonging to isopentenylflavonol compounds, with multiple pharmacological activities such as immunomodulation, anti-inflammation, antioxidative stress, anti-tumor and aging, anti-osteoporosis and other multiple pharmacological activities, which is effective in neurological, immunological, oncological, endocrinological, cardio-cerebral, cerebral, vascular and musculoskeletal system disorders, especially in the skeletal system diseases, with a multichannel and multi-targeted active effect,in particular, it has multichannel and multi-target active effects on skeletal system diseases, and has potential application advantages in articular cartilage damage diseases. Icariin can promote the repair of articular cartilage damage by promoting chondrocyte proliferation and differentiation, inhibiting excessive apoptosis, decreasing the release of inflammatory factors, inhibiting the remodeling of subchondral bone structure, promoting the synthesis of extracellular matrix in articular cartilage, and promoting the migration and chondrogenic differentiation of bone marrow mesenchymal stem cells, and many other mechanisms of action. Now, we review the different repairing effects played by icariin in the treatment of articular cartilage damage diseases and its mechanism, in order to provide reference basis for in-depth research and related drug development.

國(guó)家自然科學(xué)基金面上項(xiàng)目（82074470；51573137）