近年研究已證實，氧化應(yīng)激是造成肝損傷的重要因素，研究發(fā)現(xiàn)核因子E2相關(guān)因子2（Nrf2）/血紅素氧合酶-1（HO-1）可以通過調(diào)控氧化應(yīng)激以緩解肝損傷。中藥單體或中藥復方可以通過調(diào)控該信號通路減少氧化應(yīng)激、鐵死亡、炎癥和細胞焦亡的發(fā)生以緩解肝損傷。對中藥中的黃酮類、多糖、酚酸、甾體類等有效成分通過 Nrf2/HO-1信號通路在氧化應(yīng)激與肝損傷之間的相互作用進行綜述，對于尋求靶向 Nrf2/HO-1信號通路發(fā)揮緩解肝損傷作用的中藥提供依據(jù)，同時為中藥治療肝損傷作用機制的深入研究提供參考。

Oxidative stress is an important factor in liver injury, and studies have found that nuclear factor E2-related factor 2 (Nrf 2)/ heme oxygenase-1 (HO-1) can alleviate liver injury by regulating oxidative stress. Traditional Chinese medicine (TCM) monomers or TCM compounds can alleviate liver injury by regulating this signaling pathway to reduce the occurrence of oxidative stress, ferroptosis, inflammation and pyroptosis. This article integrates the active ingredients such as flavonoids, polysaccharides, phenolic acids, and sterols in TCM to review the interaction between oxidative stress and liver injury through this signaling pathway, which provides strong evidence for seeking TCM that targets the Nrf 2/HO-1 signaling pathway to play a role in alleviating liver injury, provides effective ideas for further exploring the multi-faceted drug effects of effective substances in TCM, and provides a reference for the development of pharmacodynamics and in-depth research on the mechanism of action of TCM.

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國家自然科學基金面上項目（81973484）；國家自然科學基金青年項目（82304736）；南京中醫(yī)藥大學青年基金項目（XZR2021085）