抑郁癥作為一種精神障礙性疾病，嚴重危害患者身心健康。目前臨床治療抑郁癥多以化學(xué)藥物為主，這類藥物主要通過不同作用途徑增加突觸間隙單胺類神經(jīng)遞質(zhì)的濃度，改善患者抑郁癥狀。抑郁癥治療周期較長，盡管化學(xué)藥物可以在短期內(nèi)發(fā)揮療效，長期服用時不良反應(yīng)明顯。傳統(tǒng)中醫(yī)藥在治療精神類疾病方面歷史悠久、經(jīng)驗豐富，對于抑郁癥的防治具有重要意義。單胺類神經(jīng)遞質(zhì)的調(diào)節(jié)仍是臨床治療抑郁癥最主要的方式，立足于中醫(yī)基礎(chǔ)理論，主要對臨床常用單味中藥（茯苓、當歸、柴胡、白芍、酸棗仁、白術(shù)、遠志、合歡皮）及復(fù)方（逍遙散、開心散、柴胡疏肝散、越鞠丸、半夏厚樸湯）通過調(diào)控單胺類神經(jīng)遞質(zhì)治療抑郁癥的作用機制進行綜述，以期發(fā)揮傳統(tǒng)中醫(yī)藥治療優(yōu)勢，為抑郁癥的中西醫(yī)結(jié)合治療提供參考。

Depression, as a mental disorder, seriously endangers the physical and mental health of patients. At present, chemical drugs are mainly used in clinical treatment of depression. These drugs mainly increase the concentration of monoamine neurotransmitters in synaptic gaps through different pathways of action, improving the symptoms of depression in patients. Depression lasts for a long period of time, although chemical drugs can have short-term therapeutic effects, adverse reactions are significant when taken for a long time. Traditional Chinese medicine has a long history and rich experience in treating mental illnesses, and is of great significance for the prevention and treatment of depression. The regulation of monoamine neurotransmitters is still the most important way to treat depression in clinical practice. This article reviews the mechanism of action of commonly used traditional Chinese medicine (Poria, Angelica Sinensis Radix, Bupleuri Radix, Paeoniae Radix Alba, Ziziphi Spinosae Semen, Atractylodis Macrocephalae Rhizoma, Polygalae Radix, Albiziae Cortex) and its compound (Xiaoyao Powder, Kaixin Powder, Chaihu Shugan Powder, Yueju Pill, Banxia Houpo Decoction) in treating depression by regulating monoamine neurotransmitters based on the basic theory of traditional Chinese medicine, in order to leverage the advantages of traditional Chinese medicine treatment and provide reference for the integrated diagnosis and treatment of depression.

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