心肌缺血是臨床常見(jiàn)病，中醫(yī)藥在緩解心肌缺血損傷的防治中表現(xiàn)出良好的效果，其作用機(jī)制是研究熱點(diǎn)。縫隙連接蛋白43（Cx43）是介導(dǎo)相鄰心肌細(xì)胞間電耦合的縫隙連接（GJ）的主要成分。在心肌缺血時(shí)，心肌細(xì)胞Cx43表達(dá)和磷酸化水平及空間分布的異常，可通過(guò)影響GJ功能參與心肌缺血損傷發(fā)生發(fā)展。目前中藥治療心肌缺血疾病研究較多的集中在中藥單體及有效成分和復(fù)方方面，歸納總結(jié)中藥單體及有效成分（主要有龍血竭總黃酮、當(dāng)歸黃酮、烏腺金絲桃總黃酮、銀杏黃酮、三七總皂苷、金絲桃苷、紅景天苷、黃芪甲苷、槐果堿、川芎嗪、蝙蝠葛堿、白藜蘆醇、丹參素）和中藥復(fù)方及制劑（主要有益氣活血方、穩(wěn)心顆粒、復(fù)方黃芪養(yǎng)心合劑、復(fù)脈湯、烏頭赤石脂丸方、養(yǎng)心定悸膠囊、枳實(shí)薤白桂枝湯、壯通飲、柴胡三參膠囊、參松養(yǎng)心膠囊）通過(guò)調(diào)控Cx43而改善GJ功能、減輕心肌缺血損傷的研究進(jìn)展，以期為中醫(yī)藥新產(chǎn)品開(kāi)發(fā)以及心肌缺血臨床用藥提供理論指導(dǎo)。

Myocardial ischemia is a common clinical disease. Traditional Chinese medicine has a clear effect on the prevention and treatment of myocardial ischemia injury, and its mechanism is a hot research topic. Connexion 43(Cx43) is a major component of gap junctions that mediate electrical coupling between adjacent cardiomyocytes. During myocardial ischemia, the abnormal distribution, expression and phosphorylation of Cx43 in cardiomyocytes may contribute to the development of myocardial ischemia by affecting gap junction function.This paper summarized the research progress of traditional Chinese medicine monomers and their active components(including sanguis draconis flavones,flavonoids in angelica sinensis, flavonoids in hypericum attenuatum choisy, ginkgetin, panax notoginseng saponins, hyperoside, salidroside, astragaloside IV, sophocarpine, ligustrazine, dauricine, resveratrol, danshensu ), as well as traditional Chinese medicine compounds and preparations (including Yiqi Huoxue Prescription, Wenxin Granules, Compound Huangqi Yangxin Mixture, Fumai Decoction, Wutou Chishishhi Pill Formula, Yangxin Dingji Capsule, Zhishi Xiebai Guizhi Decoction, Zhuangtong Yin, Chaihu Sanshen Capsule, Shensong Yangxin Capsule), in improving gap junction function and alleviating myocardial ischemia injury by regulating Cx43, in order to provide theoretical guidance for the development of new traditional Chinese medicine products and clinical use of myocardial ischemia.

R285.5

江蘇省高等學(xué)?；A(chǔ)科學(xué)（自然科學(xué)）面上項(xiàng)目（21KJB310001，24KJD310003）；江蘇省 2023 年大學(xué)生創(chuàng)新創(chuàng)業(yè)訓(xùn)練項(xiàng)目（202313980026Y）；連云港市重點(diǎn)研發(fā)計(jì)劃基金項(xiàng)目（SF2249）