目的 分析四神丸的研究現(xiàn)狀及發(fā)展趨勢。方法 檢索中國學(xué)術(shù)期刊全文數(shù)據(jù)庫（CNKI）、萬方數(shù)據(jù)知識服務(wù)平臺、維普生物醫(yī)學(xué)數(shù)據(jù)庫（VIP）從2000年1月1日－2024年3月12日收錄的四神丸基礎(chǔ)研究和臨床研究的中文文獻(xiàn)。基于文獻(xiàn)計量學(xué)方法，借助文獻(xiàn)管理NoteExpress V3.0和可視化作圖軟件CiteSpace6.2.R6對數(shù)據(jù)進(jìn)行整理與可視化分析，并繪制知識圖譜。結(jié)果 四神丸基礎(chǔ)研究與臨床研究分別納入文獻(xiàn)128、401篇，年發(fā)文量總體呈波動上升趨勢；基礎(chǔ)研究有多個研究團(tuán)隊形成，其中劉端勇團(tuán)隊有較大影響力，臨床研究尚未形成較大影響力的團(tuán)體；基礎(chǔ)研究機(jī)構(gòu)形成了以甘肅中醫(yī)藥大學(xué)為中心的較大合作網(wǎng)絡(luò)，臨床研究機(jī)構(gòu)尚未形成較大的合作網(wǎng)絡(luò)；基礎(chǔ)研究的熱點以潰瘍性結(jié)腸炎、信號通路、腸道菌群等為主，臨床研究以潰瘍性結(jié)腸炎、臨床療效、名家經(jīng)驗等熱點為主。結(jié)論 現(xiàn)階段四神丸的基礎(chǔ)和臨床研究取得了顯著成果，其基礎(chǔ)研究正逐步深入，特別是在細(xì)胞凋亡、自噬、能量代謝和腸道菌群方面，以期解析其調(diào)節(jié)機(jī)制，促進(jìn)更廣泛的臨床應(yīng)用。

Objective To analyze the current research status and development trends in the field of Sishen Pills studies. Methods Chinese literature on the basic and clinical research of Sishen Pills published between January 1, 2000, and March 12, 2024, was retrieved from CNKI, Wanfang, and VIP databases. Using bibliometric methods, the data were organized and visualized with NoteExpress V3.0 and CiteSpace 6.2.R6, and a knowledge map was created. Results A total of 128 articles on basic research and 401 articles on clinical research were included, showing a fluctuating upward trend in annual publication volume. Several research teams have formed in basic research, with the team led by Liu Duanyong being notably influential. However, no influential groups have emerged in clinical research. A large collaborative network centered around Gansu University of Chinese Medicine has formed in basic research, while clinical research institutions have yet to form significant collaborative networks. Hotspots in basic research mainly include ulcerative colitis, signaling pathways, and gut microbiota, while clinical research focuses on ulcerative colitis, clinical efficacy, and renowned experts' experiences. Conclusion At the current stage, significant achievements have been made in both the basic and clinical research of Sishen Pills. The foundational studies on Sishen Pills are progressively deepening, particularly in the areas of apoptosis, autophagy, energy metabolism, and intestinal microbiota, aiming to elucidate their regulatory mechanisms to foster broader clinical applications.

R96

國家自然科學(xué)基金資助項目（82160870）;江西省自然科學(xué)基金資助項目（20224BAB206099）;江西省中醫(yī)藥中青年骨干人才項目培養(yǎng)計劃（贛中醫(yī)藥科教字〔2022〕7號）;江西中醫(yī)藥大學(xué)科技創(chuàng)新團(tuán)隊（CXTD22009）