目的 分析2000—2022年逍遙散研究現(xiàn)狀，并預(yù)測其發(fā)展趨勢，為該復(fù)方的進一步研究提供借鑒。方法 利用中國學(xué)術(shù)期刊全文數(shù)據(jù)庫（CNKI）和Web of Science（WoS）核心集數(shù)據(jù)庫，檢索逍遙散相關(guān)文獻，使用CiteSpace軟件對發(fā)文量趨勢、作者、機構(gòu)、關(guān)鍵詞等進行可視化分析。結(jié)果 經(jīng)數(shù)據(jù)清洗，得到中文文獻956篇，英文文獻225篇；自2000年以來，逍遙散發(fā)文量呈逐年上升趨勢；陳家旭（北京中醫(yī)藥大學(xué)）、秦雪梅（山西大學(xué)）、曾南（成都中醫(yī)藥大學(xué)）是該領(lǐng)域發(fā)文量前3的作者，其所在單位同樣為主要研究機構(gòu)；中文文獻主要集中在抑郁癥、乳腺癌及月經(jīng)不調(diào)等方面，英文文獻主要聚焦在抑郁癥方面；近年來逍遙散研究熱點逐漸由乳腺癌、月經(jīng)不調(diào)、黃褐斑等向抗抑郁領(lǐng)域發(fā)展，其抗抑郁癥機制主要集中在單胺類神經(jīng)遞質(zhì)、神經(jīng)內(nèi)分泌、神經(jīng)營養(yǎng)因子、能量代謝、腸道菌群、免疫等方面。但是，目前在逍遙散抗抑郁研究方面存在一些復(fù)方應(yīng)用層面的問題，包括藥味組成比例不統(tǒng)一、用藥劑量范圍過大、單味藥是否炮制以及提取方法各有不同等，這將造成所制備的提取物存在較大差異，因此所引起的藥效及其作用機制可能也有所不同，這些問題制約了其長遠發(fā)展。結(jié)論 逍遙散的研究正處于快速發(fā)展階段，臨床應(yīng)用及實驗研究方面已有大量積累，但因抑郁癥發(fā)病機制復(fù)雜，逍遙散抗抑郁機制方面的研究仍需繼續(xù)深入，如利用同位素示蹤代謝組學(xué)、腸道微生物組學(xué)、單細胞轉(zhuǎn)錄組學(xué)等對其能量代謝、菌群調(diào)節(jié)和免疫調(diào)控的作用機制進行深入研究，為逍遙散的抗抑郁研究帶來突破性創(chuàng)新。

Objective To analyze the research status of Xiaoyao Powder over the past 20 years (from 2000 to 2022) and predicted its development trends to provide insights for further research on this formula. Methods Relevant literature on Xiaoyao Powder was retrieved from the China National Knowledge Infrastructure (CNKI) and Web of Science (WoS) core collection databases. CiteSpace software was used for visual analysis of publication trends, authors, institutions, and keywords. Results After data cleaning, 956 Chinese and 225 English publications were obtained. The number of publications on Xiaoyao Powder has increased annually since 2000. Chen Jiaxu (Beijing University of Chinese Medicine), Qin Xuemei (Shanxi University), and Zeng Nan (Chengdu University of Traditional Chinese Medicine) are the top three authors in terms of publication volume, with their respective institutions being the major research institutions. Chinese literature mainly focuses on depression, breast cancer, and menstrual disorders, and English literature predominantly concentrates on depression. In recent years, the research focus of Xiaoyao Powder has gradually developed from breast cancer, menstrual disturbance, melasma, etc., to the field of anti-depression. Its anti-depression mechanism mainly focuses on monoamine neurotransmitters, neuroendocrine, neurotrophic factors, energy metabolism, intestinal flora, immunity and other aspects. However, at present, there are some problems in the application of Xiaoyao Powder in the study of anti-depression, including the difference in the composition ratio of drug flavor, the large dosage range, and the different processing and extraction methods of single flavor drugs, which will cause great differences in the prepared extracts, so the drug effects and mechanism of action may also be different. Conclusion The research on Xiaoyao Powder is in a stage of rapid development, and a large amount of clinical applications and experimental studies have been accumulated. However, due to the complex pathogenesis of depression, the research on the anti-depression mechanism of Xiaoyao Powder still needs to be further deepened. For example, isotope tracer metabolomics, intestinal microbiome and single cell transcriptomics were used to conduct in-depth studies on the mechanisms of its energy metabolism, flora regulation and immune regulation, which brought breakthrough innovations for the anti-depression research of Xiaoyao Powder.

R285

國家自然科學(xué)基金資助項目（82204656）