近年來，隨著腫瘤發(fā)病率和死亡率的顯著上升，尋找新的治療模式以提高療效成為腫瘤學領(lǐng)域的重要研究方向。熱療是繼手術(shù)、化療、放療和免疫治療之外的一種腫瘤治療手段，逐漸受到關(guān)注。熱療通過提高腫瘤組織溫度，誘導(dǎo)腫瘤細胞壞死，釋放腫瘤抗原，改變腫瘤免疫微環(huán)境，清除免疫抑制性細胞，從而增強機體的抗腫瘤免疫反應(yīng)。此外，熱療還可上調(diào)腫瘤細胞表面的黏附分子和熱休克蛋白的表達，激活細胞毒性T淋巴細胞和其他免疫效應(yīng)細胞，進一步促進免疫反應(yīng)。熱療與免疫治療的聯(lián)合在多種腫瘤模型中顯示出協(xié)同效應(yīng)，顯著提高抗腫瘤治療效果。系統(tǒng)總結(jié)熱療對腫瘤免疫功能的作用機制及其與免疫治療的聯(lián)合策略，旨在為未來腫瘤治療的研究和應(yīng)用提供理論依據(jù)和新思路。

In recent years, with the significant increase in cancer incidence and mortality rates, finding new treatment modalities to improve efficacy has become an important research direction in the field of oncology. Hyperthermia, as a cancer treatment method following surgery, chemotherapy, radiotherapy, and immunotherapy, has gradually attracted attention. Hyperthermia enhances the body's anti-tumor immune response by raising the temperature of tumor tissues, inducing tumor cell necrosis, releasing tumor antigens, altering the tumor immune microenvironment, and eliminating immunosuppressive cells. Additionally, hyperthermia can upregulate the expression of adhesion molecules and heat shock proteins on the surface of tumor cells, activating cytotoxic T lymphocytes and other immune effector cells, thereby further promoting the immune response. Current research indicates that the combination of hyperthermia and immunotherapy shows synergistic effects in various tumor models, significantly improving treatment outcomes. This paper systematically summarizes the mechanisms of hyperthermia's effects on tumor immune function and its research progress in combination with immunotherapy, aiming to provide theoretical basis and new insights for future cancer treatment research and applications.

廣東省基礎(chǔ)與應(yīng)用基礎(chǔ)研究基金委員會資助項目（2021A1515220040）