目的 采用文獻(xiàn)計(jì)量學(xué)方法探討藥物的生殖與發(fā)育毒性研究熱點(diǎn)和發(fā)展趨勢(shì)。方法 從Web of Science核心集中收集2009—2023年相關(guān)文獻(xiàn)數(shù)據(jù)并利用CiteSpace，VOSviewer等工具進(jìn)行可視化分析。結(jié)果 共有1 962篇文獻(xiàn)納入研究，這些文獻(xiàn)多聚焦于藥理學(xué)和毒理學(xué)領(lǐng)域，但對(duì)公共衛(wèi)生、環(huán)境科學(xué)等領(lǐng)域的研究存在欠缺。近15年發(fā)文量總體呈上升趨勢(shì)，至2021年達(dá)到高峰。在101個(gè)國(guó)家/地區(qū)中，美國(guó)的發(fā)文量最多且來(lái)自美國(guó)的哈佛大學(xué)被認(rèn)為是最高生產(chǎn)力的機(jī)構(gòu)，但其國(guó)際交流合作的深度與廣度仍待拓展。Werler MM是同時(shí)擁有最高發(fā)文量和被引頻次的作者。在766個(gè)期刊中，Reproductive Toxicology以85篇發(fā)文量位居第1位。關(guān)鍵詞和文獻(xiàn)分析表明沙利度胺、抗甲狀腺藥（ATD）、抗癲癇藥（AED）等是高頻研究藥物，毒性機(jī)制聚焦于氧化應(yīng)激、DNA損傷、細(xì)胞凋亡等。結(jié)論 藥物的生殖和發(fā)育毒性研究面向多學(xué)科發(fā)展，對(duì)公共衛(wèi)生和環(huán)境科學(xué)等研究薄弱領(lǐng)域應(yīng)加強(qiáng)關(guān)注。目前的研究重點(diǎn)聚焦于ATD、AED在內(nèi)的多種藥物毒性探索和毒理機(jī)制研究。未來(lái)應(yīng)加強(qiáng)多學(xué)科交叉應(yīng)用，積極探尋有效的抗氧化策略和減少DNA損傷及細(xì)胞凋亡的措施。

Objective To explore the research hotspot and development trend of reproductive and developmental toxicity of drugs by bibliometrics. Methods Relevant publication data from 2009 to 2023 were collected from Web of Science Core Collection and visualized with tools such as CiteSpace and VOSviewer. Results A total of 1962 literatures were included in the study, most of which focused on the fields of pharmacology and toxicology, but there was a lack of research in the fields of public health and environmental science. In the past 15 years, the number of published documents has shown an overall upward trend, reaching a peak in 2021. Among the 101 countries/regions, the United States had the largest number of publications and Harvard University from the United States was considered to be the most productive institution, but the depth and breadth of its international exchanges and cooperation still need to be expanded. Werler MM was the author with both the highest number of articles and the highest number of citations. Among the 766 journals, Reproductive Toxicology ranked first with 85 articles. Key words and literature analysis showed that thalidomide, anti-thyroid drugs (ATD), anti-epileptic drugs (AED), etc. are highly studied drugs, and the toxic mechanism focuses on oxidative stress, DNA damage, apoptosis, etc. Conclusion The research on reproductive and developmental toxicity of drugs is developing in multiple disciplines, and more attention should be paid to the weak areas such as public health and environmental science. The current research focuses on the toxicity exploration and toxicological mechanism research of various drugs including ATD and AED. In the future, interdisciplinary application should be strengthened to actively explore effective antioxidant strategies and measures to reduce DNA damage and cell apoptosis.

國(guó)家自然科學(xué)基金資助項(xiàng)目（82204938），河南省醫(yī)學(xué)科技公關(guān)計(jì)劃聯(lián)合共建項(xiàng)目（LHGJ20240427）