芍藥內(nèi)酯苷是從芍藥Paeonia lactiflora分離出來的單萜糖苷類化合物，是芍藥的主要活性成分之一，具有抗抑郁、抗炎、鎮(zhèn)痛、抗腫瘤、抗凋亡、抗氧化等藥理作用。目前，對芍藥內(nèi)酯苷抗抑郁、抗炎作用研究較多，芍藥內(nèi)酯苷在抗抑郁方面作用顯著，可能與調(diào)節(jié)單胺類神經(jīng)遞質(zhì)、抑制下丘腦-垂體-腎上腺軸（ HPA軸）亢進(jìn)、促進(jìn)腦源性神經(jīng)營養(yǎng)因子（ BDNF）表達(dá)有關(guān)，并且其可通過抑制N-甲基-D-天冬氨酸（NMDA）受體發(fā)揮快速抗抑郁的作用，具有開發(fā)成抗抑郁新藥的潛力。其次，芍藥內(nèi)酯苷的抗炎作用可能與抑制核因子κB（NF-κB）和絲裂原活化蛋白激酶（MAPK）信號通路有關(guān)，通過抑制NF-κB和MAPK信號通路抑制促炎細(xì)胞因子的表達(dá)，發(fā)揮抗炎作用。通過對芍藥內(nèi)酯苷的藥理作用進(jìn)行綜述，為進(jìn)一步對芍藥內(nèi)酯苷的藥物研發(fā)及臨床應(yīng)用提供依據(jù)。

Albiflorin is a monoterpene glycoside isolated from Paeonia lactiflora, which is one of the main active compounds in P. lactiflora. It has pharmacological effects such as anti-depression, anti-inflammation, analgesia, anti-tumor, anti-apoptosis and antioxidation. At present, there are many studies on the anti-depressant and anti-inflammatory effects of albiflorin. Albiflorin significantly exhibits anti-depressant effect by adjusting the levels of monoamine neurotransmitters, inhibiting the hypothalamicpituitary-adrenal axis (HPA axis) hyperactivity, and promoting the expression of brain-derived neurotrophic factor (BDNF). In addition, albiflorin can exert a rapid anti-depressant effect by inhibiting NMDA receptor. Based on the above evidence, albiflorin has the potential to be developed as a new anti-depressant drug. Secondly, the anti-inflammatory effect of albiflorin may be related to the inhibition of NF-κB and MAPK signaling pathways, which inhibit the expression of pro-inflammatory cytokines and play an anti-inflammatory role. In this paper, the pharmacological effects of albiflorin are reviewed, so as to provide a basis for further drug development and clinical application of albiflorin.

R285.5

現(xiàn)代中藥新質(zhì)生產(chǎn)力科技創(chuàng)新工程專項（24ZXZKSY00050）