目的 通過對近5年中藥抗癌相關(guān)研究的文獻(xiàn)分析，探析中藥抗癌研究領(lǐng)域的相關(guān)熱點(diǎn)與前沿。方法 以Web ofScience（WOS）、中國學(xué)術(shù)期刊全文數(shù)據(jù)庫（CNKI）以及維普生物醫(yī)學(xué)數(shù)據(jù)庫（VIP）等國內(nèi)外數(shù)據(jù)庫為數(shù)據(jù)源，運(yùn)用CiteSpace、Note Express等軟件對所篩選文獻(xiàn)的年度發(fā)文量、作者、機(jī)構(gòu)、關(guān)鍵詞等方面進(jìn)行分析，繪制可視化圖譜，并分析目前中藥抗癌領(lǐng)域的研究熱點(diǎn)及趨勢。結(jié)果 中藥抗癌領(lǐng)域文獻(xiàn)以英文文獻(xiàn)為主，各文獻(xiàn)大多為中國各省中醫(yī)藥大學(xué)等研究機(jī)構(gòu)發(fā)表；綜合分析，各國學(xué)者較多采用網(wǎng)絡(luò)藥理學(xué)預(yù)測加細(xì)胞和動(dòng)物藥理實(shí)驗(yàn)驗(yàn)證的方式對中藥抗癌進(jìn)行研究，目前治療癌癥的研究熱點(diǎn)藥物主要為黃芪和人參、熱點(diǎn)活性成分為槲皮素和姜黃素，而最近的研究趨向?yàn)樾￠迚A、六君子湯、EGFR基因和癌癥治療中的不良反應(yīng)等。結(jié)論 中藥治療癌癥方面的研究目前仍處于快速發(fā)展階段，目前該領(lǐng)域熱點(diǎn)聚焦于中藥及中藥活性成分開發(fā)利用、方劑臨床應(yīng)用、作用機(jī)制等方面，但尚存在團(tuán)隊(duì)間缺乏大規(guī)模合作、研究深度不夠等不足。

Objective To analyze the literature on anti-cancer research in traditional Chinese medicine in the past five years, and to explore the relevant hotspots and frontiers in the field of anti-cancer research of traditional Chinese medicine. Methods Web of Science (WOS), China National Knowledge Infrastructure (CNKI) and VIP databases were used as data sources, and Cite Space, Note Express and other software were used to analyze the annual publication volume, authors, institutions, keywords and other aspects of the screened literature, and the visual map was drawn. And analyze the current research hotspots and trends in the field of traditional Chinese medicine anti-cancer. Results The literature in the field of anti-cancer of traditional Chinese medicine was mainly in English, and most of the literature was published by universities of traditional Chinese medicine and other research institutions in various provinces of China. Based on comprehensive analysis, scholars from various countries tend to use network pharmacology predictio combined with cell and animal experimental pharmacology verification to study the anti-cancer effects of traditional Chinese medicine, at present, the research hotspots for the treatment of cancer are mainly Astragali Radix and Ginseng Radix et Rhizoma, and the hot active ingredients are quercetin and curcumin, while the recent research tends to be berberine, Liujunzi decoction, EGFR gene and side effects in cancer treatment. Conclusion The research on the treatment of cancer with traditional Chinese medicine is still in the stage of rapid development, and the current hot spots in this field focus on the development and utilization of traditional Chinese medicine and its active ingredients, the clinical application of formulas, and the mechanism of action, but there are still shortcomings such as lack of large-scale cooperation between teams and insufficient research depth.

R979.1

國家中醫(yī)藥管理局科技項(xiàng)目（ GZY-KJS-2023-030）；河北省自然科學(xué)基金項(xiàng)目（ H2023423005）；河北省中醫(yī)藥管理局科研計(jì)劃項(xiàng)目（2023114、 2020130）；河北中醫(yī)學(xué)院優(yōu)秀青年基金項(xiàng)目（ YQ2020006）