阿魏酸是廣泛存在于植物中的一種功能性酚酸，也是當(dāng)歸、升麻、川芎等常用中藥的主要活性成分。它具有很強的抗氧化和抗炎活性，能有效提高血流量、抑制血小板聚集、降低血脂水平、抑制血栓形成，可用于心血管疾病的治療。通過查閱整理文獻(xiàn)，對阿魏酸藥動學(xué)研究進(jìn)行綜述，包括阿魏酸作為咖啡酸代謝物的藥動學(xué)研究、阿魏酸的吸收動力學(xué)研究、阿魏酸的代謝和排泄研究、以及阿魏酸臨床用藥安全性研究，為臨床合理應(yīng)用及給藥方案的確定提供科學(xué)依據(jù)。

Abstract: Ferulic acid is a functional phenolic acid widely found in plants and also the major active component in Angelica sinensis, szechuan lovage rhizome, and cimicifugae foetidae. Ferulic acid presents strong antioxidant activity and anti-inflammatory activity. It can improve significantly blood fluidity and reduce the serum lipids, inhibit platelet aggregation and thrombus formation, and is effective for the treatment of cardiovascular diseases. In this paper, large number of literature was consulted and the pharmacokinetic study of ferulic acid was reviewed to provide scientific support for the clinical medication of ferulic acid. This paper was processed in four main parts, including the pharmacokinetic study of ferulic acid as the metabolite of caffeic acid, the absorption research of ferulic acid, the metabolism and excretion of ferulic acid, and safety study of ferulic acid in clinic.

天津市科委應(yīng)用基礎(chǔ)研究計劃一般項目（11JCYBJC15000）