目的 探討超早期使用丁苯酞注射液對(duì)急性腦梗死患者神經(jīng)功能及側(cè)支循環(huán)建立的影響。方法 選取2014年7月—2017年7月漯河市第二人民醫(yī)院診治的急性腦梗死患者86例作為研究對(duì)象，按照入院先后順序分為對(duì)照組（42例）和觀察組（44例）。對(duì)照組給予阿替普酶靜脈溶栓治療，觀察組在阿替普酶靜脈溶栓前后給予丁苯酞注射液100 mL靜脈滴注，2次/d，兩次間隔時(shí)間為7 h，治療14 d。比較兩組患者治療前和治療14 d的臨床有效率、側(cè)支循環(huán)血流速度，比較兩組患者治療前、治療1 h、治療7 d和治療14 d的美國(guó)國(guó)立衛(wèi)生院神經(jīng)功能缺損評(píng)分（NIHSS）和日常生活能力（ADL）評(píng)分。結(jié)果 觀察組的臨床有效率為90.91%，對(duì)照組的臨床有效率為78.57%，觀察組顯著高于對(duì)照組（P<0.05）。兩組患者NIHSS評(píng)分在治療1 h、治療7 d和治療14 d均顯著低于治療前（P<0.05），且觀察組在治療1 h、治療7 d和治療14 d均顯著低于對(duì)照組（P<0.05）。兩組患者ADL評(píng)分在治療1 h、治療7 d和治療14 d均顯著高于治療前（P<0.05），且觀察組在治療1h、治療7 d和治療14 d均顯著高于對(duì)照組（P<0.05）。兩組患者治療后大腦中動(dòng)脈（MCA）流速顯著加快，大腦前動(dòng)脈（ACA）和大腦后動(dòng)脈（PCA）流速顯著減慢（P<0.05）；且治療后觀察組MCA流速與對(duì)照組相比較快（P<0.05），觀察組ACA和PCA流速與對(duì)照組相比較慢（P<0.05）。結(jié)論 超早期使用丁苯酞注射液治療急性腦梗死可顯著改善患者的神經(jīng)功能、提高生活能力，改善側(cè)支循環(huán)血流速度，取得較好的臨床療效。

Objective To explore the influence of ultra-early use of butylphthalide injection on nerve function and collateral circulation in patients with acute cerebral infarction.Methods 86 cases of acute cerebral infarction treated by Luohe second people's hospital from July 2014 to July 2017 were selected and divided into control group (42 cases) and observation group (44 cases) according to the order of admission. The control group was treated with alteplase thrombolytic therapy, the observation group was treated butylphthalide injection on the basis of control group. The clinical efficacy and collateral circulation blood velocity were compared between the two groups before and after treatment. NIHSS and ADL score were compared in 1h after treatment, 7d after treatment and 14 d after treatment between the two groups.Results The clinical efficacy of the observation group was 90.91%, the control group was 78.57%, the observation group was significantly higher than the control group (P<0.05); NIHSS score after treatment 1 h, 7 d and 14 d in both groups were significantly lower than before treatment (P<0.05), and the observation group after treatment 1 h, 7 d and 14 d were significantly lower than control group (P<0.05); ADL scores after treatment 1 h, 7 d and 14 d in both groups were significantly higher than before treatment (P<0.05), and the observation group after treatment 1 h, 7 d and 14 d were significantly higher than control group (P<0.05); MCA flow speed in both group after treatment, ACA and PCA slows down (P<0.05), MCA velocity faster in observation group than the control group after treatment (P<0.05), ACA and PCA velocity slow in observation group compared with the control group (P<0.05). Conclusions The treatment of acute cerebral infarction with butylphthalein injection in the ultra-early can significantly improve the patients' neurological function, improve their living ability, improve the blood flow speed of collateral circulation, and achieve better clinical efficacy.