目的 評價疏風(fēng)解毒膠囊聯(lián)合西醫(yī)常規(guī)治療對慢性阻塞性肺疾病急性加重期（AECOPD）患者肺功能的影響。方法 收集就診于蚌埠市第一人民醫(yī)院呼吸科患有AECOPD的70例患者，隨機分為對照組與觀察組。其中，對照組予以西醫(yī)常規(guī)方案治療，觀察組采用西醫(yī)常規(guī)方案合并疏風(fēng)解毒膠囊治療，療程均為10 d。觀察所有患者在治療期間動脈血氣、肺功能及痰液和血液中丙二醛等變化情況。結(jié)果 治療10 d后，兩組患者的血氣分析較治療前顯著改善，同組治療前后比較差異有統(tǒng)計學(xué)意義（P<0.05）；且觀察組患者的動脈血氧分壓（pO₂）指標優(yōu)于對照組，差異有統(tǒng)計學(xué)意義（P<0.05）。治療10 d后患者FEV1/L和FEV1/FVC指標均顯著改善，同組治療前后比較差異有統(tǒng)計學(xué)意義（P<0.05）；且觀察組患者FEV1/L和FEV1/FVC指標優(yōu)于對照組，差異有統(tǒng)計學(xué)意義（P<0.05）。治療后，兩組患者的痰液和血液中丙二醛濃度較治療前顯著降低，同組治療前后比較差異有統(tǒng)計學(xué)意義（P<0.05）；且觀察組患者血液丙二醛濃度低于對照組，差異有統(tǒng)計學(xué)意義（P<0.05）。結(jié)論 疏風(fēng)解毒膠囊聯(lián)合西醫(yī)常規(guī)治療有利于改善AECOPD患者肺功能指標，減輕患者臨床癥狀。

Objective To evaluate the efficacy of Shufeng Jiedu Capsule combined with western medicine in the pulminary function of AECOPD patients. Methods 70 patients with AECOPD were choosed and randomly divided into study group and observation group, which group were 50 cases respectively. The control group was treated with routine treatment of Western Medicine. The observation group patients were treated in routine treatment combined with Shufeng Jiedu Capsule. After 10 days treatment, compared the two groups of changes in arterial blood gas, lung function, sputum and malondialdehyde in blood. Results After treatment, blood gas analysis of two groups of patients were improved significantly (P<0.05), and the arterial partial pressure of oxygen (PaO₂) index in observation group is better than the control group (P<0.05). After treatment, the observation group FEV1/L and FEV1/FVC index is better than the patients in the control group (P<0.05), and the concentrations of malondialdehyde in sputum and blood of two groups were significantly lower than those before treatment (P<0.05), and the concentration of malondialdehyde in the observation group was lower than that in the control group (P<0.05).Conclusion Shufeng Jiedu Capsule combined with western medicine is beneficial to improve the pulmonary function index of AECOPD patients and reduce the clinical symptoms of the patients.