目的 用中紅外光譜技術(shù)對(duì)6家企業(yè)生產(chǎn)的黃柏、茯苓及熟地黃3種配方顆粒進(jìn)行質(zhì)量考察，分析了不同企業(yè)配方顆粒的一致性。方法 以峰位、峰形、相對(duì)峰強(qiáng)度或主要標(biāo)準(zhǔn)峰個(gè)數(shù)等為考察指標(biāo)，對(duì)不同企業(yè)生產(chǎn)的同一品種的配方顆粒與標(biāo)準(zhǔn)藥材及自制提取物的譜圖進(jìn)行對(duì)比，分析三者之間的差異（相似度）。結(jié)果 6家企業(yè)的黃柏配方顆粒在1 604、1 507 cm^-1處特征峰的相對(duì)峰高的變化不同，其原藥材質(zhì)量可能存在差異；茯苓配方顆粒因采用輔料種類(lèi)不一，中紅外光譜圖差異明顯；熟地黃配方顆粒因原藥材投料比不同，隨著輔料含量的增加，與熟地黃提取物的相關(guān)系數(shù)降低。結(jié)論 中紅外光譜具有操作簡(jiǎn)單、快速、專(zhuān)屬性強(qiáng)、不需要對(duì)樣品進(jìn)行分離等優(yōu)點(diǎn)，尤其是揭示不同企業(yè)的同一種配方顆粒因采用原藥材的品質(zhì)、輔料不同等因素所造成質(zhì)量差異，因此，中紅外光譜技術(shù)為保證配方顆粒的均一性提供了客觀的分析手段和數(shù)據(jù)支撐。

Objective The quality investigation on Phellodendron, Poria Cocos and Rehmannia glutinosa formula granules by midinfrared spectroscopy, which analyzes different enterprises of formula particles of consistency. Methods In the peak position, peak shape, relative peak intensity or the number of the main standard peaks as the investigation index, the spectrogram of formula granules from the six enterprises in the same variety were compared with rude drug and self-made extract, analyzed the differences between the three of them(similarity). Results The differences in the relative absorption peak heights at 1 604 cm^-1 and 1 507 cm^-1 are different, and the quality of the original medicinal materials may be different. The types of accessories of Poria formula particles were different, the mid-infrared spectroscopy of them were significantly different. Rehmannia glutinosa formula granule because of the different dosing ratio of raw materials, the correlation coefficient for Rehmannia glutinosa extract was decreased with the increase in the amount of excipients. Conclusions Mid-infrared spectroscopy has the advantages of simple operation, rapidity, high specificity and no separation of samples, especially to revealed the quality difference of the same formula particles from different enterprises was because of the quality of raw materials, processing methods, extraction technology, different accessories and other factors, in order to ensure the consistency and stability of granule, it provides an objective analysis method and data support.

天津市科技計(jì)劃項(xiàng)目（16ZXZYNC00060，15YDLJSY00100）