+、CD4+、CD8+、CD4+/CD8+水平均無顯著差異;治療后,兩組患兒CD3+、CD4+、CD4+/CD8+水平均顯著升高,CD8+水平顯著降低,同組治療前后比較差異有統(tǒng)計學(xué)意義(P<0.05);其中聯(lián)合組患兒CD3+、CD4+、CD4+/CD8+水平均顯著高于對照組,CD8+水平顯著低于對照組,組間差異均有統(tǒng)計學(xué)意義(P<0.05)。治療前,兩組患兒IL-6、IL-8、IL-10水平均無顯著性差異;治療后,兩組患者IL-6、IL-8、IL-10水平均顯著降低,同組治療前后比較差異有統(tǒng)計學(xué)意義(P<0.05);其中聯(lián)合組顯著低于對照組,組間差異有統(tǒng)計學(xué)意義(P<0.05)。結(jié)論 川芎嗪聯(lián)合阿奇霉素對紅霉素耐藥大葉肺炎患兒有較好的療效,其治療作用的發(fā)揮與調(diào)節(jié)機體免疫環(huán)境有關(guān),能增加免疫力,減輕炎癥反應(yīng),從而促進患兒的康復(fù)。;Objective To investigate the curative effect and cytokines of azithromycin and ligustrazine on children with erythromycinresistant lobar pneumonia.Methods 180 cases of children with erythromycin-resistant lobar pneumonia were selected as the research object and randomly divided into azithromycin group and combination group, 90 cases in each group. Azithromycin group given azithromycin, the combination group was given ligustrazine treatment on the basis of Azithromycin group. The curative effect, immunoglobulin level and inflammatory factor level were observed and compared between the two groups.Results After treatment, the effective rate of the acyclovir group was 77.78%, and that in the combined group was 87.78%. The effective rates between the two groups were significantly different (P<0.05). The levels of CD3+, CD4+, CD8+ and CD4+/CD8+ in both groups were significantly improved, and the improvement in the combination group was higher (P<0.05). The levels of IL-6, IL-8 and IL-10 in both groups were significantly decreased, especially in the combination group (P<0.05).Conclusions Azithromycin combined with Ligustrazine in children with erythromycin-resistant lobar pneumonia has better curative effect, and its therapeutic effect is related to the regulation of immune environment, which can increase the immunity and reduce the inflammatory reaction so as to promote the rehabilitation of children."/>