目的 探討丙戊酸鎂聯(lián)合多奈哌齊對老年癡呆認(rèn)知行為的影響。方法 以2012年9月—2017年9月新疆醫(yī)科大學(xué)第六附屬醫(yī)院60例老年癡呆患者為研究對象，根據(jù)隨機(jī)數(shù)字表法將入選的患者平均分為對照組和觀察組，每組各30例?；颊呷朐汉缶鶉谄浣狗糜洃浽鰪?qiáng)劑、胰島素、抗膽堿能及精神興奮性藥物，停藥一周后，對照組患者口服鹽酸多奈哌齊片5 mg/次，1次/d，每晚睡前服用，連續(xù)治療1周后，劑量增至10 mg/次，1次/d，連續(xù)治療3個月。觀察組患者在對照組的基礎(chǔ)上聯(lián)合口服丙戊酸鎂緩釋片250 mg/次，2次/d，連續(xù)治療3個月。比較兩組患者的臨床療效及治療前后認(rèn)知功能及精神行為、日常生活能力、抑郁情緒及睡眠質(zhì)量評分變化。結(jié)果 觀察組及對照組患者的治療總有效率分別為86.67%、66.67%，兩組比較存在顯著差異性（P<0.05）。治療前兩組患者的精神狀態(tài)檢查量表（MMSE）評分、AD評定量表（ADAS）評分、ADL評分、汗密頓抑郁量表（HAMD）評分、匹茨堡睡眠質(zhì)量指數(shù)量表（PSQI）評分比較無顯著性差異；治療后，兩組的MMSE、ADL、HAMD、ADAS及PSQI評分均顯著降低，同組治療前后比較差異有統(tǒng)計學(xué)意義（P<0.05）；且觀察組顯著優(yōu)于對照組，組間差異有統(tǒng)計學(xué)意義（P<0.05）。結(jié)論 丙戊酸鎂聯(lián)合多奈哌齊可有效提高患者的臨床療效及日常生活能力，改善患者的認(rèn)知行為、抑郁情緒及睡眠質(zhì)量，在老年癡呆的治療中具有重要的應(yīng)用價值。

Objective To explore effect of magnesium valproate combined with donepezil in the treatment of patients with Alzheimer's cognitive behavior.Methods 60 patients with Alzheimer's disease were selected as the subjects from September 2012 to September 2017. According to random number table method, all patients were divided into control group and study group. 30 patients in each group were treated with magnesium valproate treatment, the experimental group on the basis of this combination of donepezil treatment, the clinical effect, cognitive function and mental behavior, daily living ability (ADL), depression mood and sleep quality score changing before and after treatment were observed between two groups.Results The total effective rate in the experimental group were obviously higher than those in the control group (86.67% vs 66.67%) (P<0.05). There were no significant differences in MMSE, ADL, HAMD, ADAS and PSQI scores between the two groups before treatment. After treatment, the MMSE, ADL, HAMD, ADAS and PSQI scores of the two groups were significantly reduced, and the study group was significantly, and the difference was statistically significant (P<0.05). Conclusion Magnesium valproate combined with donepezil in the treatment of patients with Alzheimer's disease can effectively increase clinical efficacy, daily living ability, and improve the patient's cognitive behavior, depressive mood, sleep quality, which has important application value.