自噬過程受到一系列復雜信號分子的調控?；A水平的自噬在清除異常積聚的蛋白質、長壽命蛋白以及受損細胞器、維持細胞內穩(wěn)態(tài)和細胞生存中扮演重要角色。阿爾茨海默?。ˋlzheimer’s disease，AD）是一種以進行性認知障礙和記憶力損害為主的腦部神經(jīng)退行性疾病，其發(fā)病機制尚未明確，目前仍無有效的治療方法。介紹自噬和阿爾茨海默癥的關系和藥物治療，旨在為AD相關藥物的開發(fā)及合理利用提供實驗依據(jù)。

The process of autophagy is regulated by a series of complex signal molecules. Basal levels of autophagy play an important role in clearing abnormally accumulated proteins, long-lived proteins and damaged organelles, maintaining cell homeostasis, and cell survival. Alzheimer's disease (AD) is a brain neurodegenerative disease mainly characterized by progressive cognitive impairment and memory impairment. Its pathogenesis is not yet clear, and there is still no effective treatment. This article describes the relationship between autophagy and Alzheimer's disease and drug treatment, aims to provide an experimental basis for the rational development and utilization of AD-related drugs.