苦參堿類生物堿（苦參堿、氧化苦參堿、槐果堿、槐定堿）可通過(guò)下調(diào)肉瘤細(xì)胞表達(dá)各種細(xì)胞生長(zhǎng)因子（如血管內(nèi)皮生長(zhǎng)因子等），阻滯血管新生，間接抑制肉瘤生長(zhǎng)；還能直接抑制肉瘤細(xì)胞增殖并促進(jìn)其凋亡，產(chǎn)生抗肉瘤作用?？鄥A類生物堿還可通過(guò)下調(diào)P-糖蛋白、肺耐藥蛋白、DNA拓?fù)洚悩?gòu)酶的過(guò)度表達(dá)，解除肉瘤細(xì)胞的多藥耐藥性，提高其對(duì)化療藥的敏感性。

Matrine-type alkaloids (matrine, oxymatrine, sophocarpine, sophoridine) can indirectly inhibit sarcoma growth and angiogenesis by down-regulating the expression of cellular growth factors (eg. vascular endothelial growth factor) of sarcoma cells. Also, matrine-type alkaloids can directly inhibit proliferation and increase apoptosis of sarcoma cells to exert anti-sarcoma effects. By down-regulating the overexpression of P-glycoprotein, lung resistance protein, and DNA topoisomerase, matrine-type alkaloids relieve multi-drug resistance of sarcoma cells to enhance its sensitivity to chemotherapeutics.