目的 基于整合藥理學平臺探索葛根芩連湯治療小兒肺炎的作用機制。方法 本研究通過中藥整合藥理學平臺，通過輸入葛根、黃芩、黃連、甘草四味藥及肺炎獲取藥物和疾病靶標，然后進行蛋白質(zhì)-蛋白質(zhì)相互作用及網(wǎng)絡(luò)構(gòu)建，進一步進行基因功能和通路富集分析，進行葛根芩連湯治療肺炎的"中藥-成分-靶標-通路"多維網(wǎng)絡(luò)分析。結(jié)果 藥物作用于疾病的關(guān)鍵通路包括細胞生長和死亡、傳染病、細胞凋亡、免疫系統(tǒng)、趨化因子信號通路、B細胞受體信號通路、T細胞受體信號通路、血小板活化、胃酸分泌等。藥物潛在靶標為GCK、COX7C、ATP1A1、ADCY2。結(jié)論 葛根芩連湯治療小兒肺炎的機制可能通過與能量代謝及消化系統(tǒng)相關(guān)物質(zhì)唾液等相關(guān)，推測其具有潛在的關(guān)系。

Objective To explore the mechanism of Gegen Qinlian Decoction in the treatment of children with pneumonia, and to find out the path and target of Gegen Qinlian Decoction in the treatment of children with pneumonia. Methods Through the integrated pharmacology platform of traditional Chinese medicine, the drug and disease targets were obtained by inputting puerarin, jaundice, berberine, licorice and pneumonia, and then protein-protein interaction and network construction were carried out to further carry out gene function and pathway enrichment. analysis. Results Key pathways for drug action in disease including cell growth and death, infectious diseases, apoptosis, immune system, chemokine signaling pathway, B cell receptor signaling pathway, T cell receptor signaling pathway, platelet activation, gastric acid Secretion and so on. Potential drug targets are GCK, COX7C, ATP1A1, and ADCY2. Conclusion The mechanism of Gegen Qinlian Decoction in the treatment of children with pneumonia may be presumed to have a potential relationship through the relationship with energy metabolism and salivary system related substances