目的 探討林下山參方酒精滲漉液（MCGPAP）對正常大鼠交配功能及腎陽虛大鼠勃起功能的影響。方法 以西地那非及丙酸睪酮作為陽性對照，雄性SD大鼠ip氫化可的松注射液復(fù)制腎陽虛模型，MCGPAP高、中、低劑量（2.25、1.125、0.562 5 mL/kg，換算為生藥劑量為46.44、23.22、11.61 g/kg）連續(xù)給藥14 d，檢測MCGPAP對正常大鼠體質(zhì)量、交配能力、精子數(shù)、性腺指數(shù)的影響；檢測MCGPAP單次及連續(xù)給藥14 d對腎陽虛大鼠體質(zhì)量、勃起功能、性腺指數(shù)的影響。結(jié)果 MCGPAP對正常大鼠體質(zhì)量、性腺指數(shù)無明顯影響；與空白對照組比較，MCGPAP高、中、低劑量能增加正常大鼠30 min內(nèi)插入次數(shù)及30 min內(nèi)射精次數(shù)（P<0.05）；中劑量還能縮短插入潛伏期，高劑量能增加正常大鼠精子數(shù)，與空白對照、溶媒對照組比較均差異顯著（P<0.05）。對腎陽虛大鼠，MCGPAP各劑量單次給藥對其勃起功能、體質(zhì)量無明顯影響；MCGPAP給藥14 d對大鼠體質(zhì)量無明顯影響；與模型組比較，中劑量能提高其勃起百分率、勃起次數(shù)（P<0.05）；MCGPAP低劑量組腎臟指數(shù)較模型組及溶媒對照組明顯增加（P<0.05），前列腺+精囊腺指數(shù)較溶媒對照組明顯增加（P<0.05）。結(jié)論 林下山參方具有增強(qiáng)正常大鼠交配功能及腎陽虛大鼠勃起功能的作用。

Objective To explore the effect of mountain cultivated ginseng prescription alcohol percolate (MCGPAP) on the mating function of normal rats and the erectile function of rats with kidney-yang deficiency. Methods Sildenafil and testosterone propionate were used as positive control. The kidney yang deficiency model was copied by ip injecting with hydrocortisone injection in male SD rats. MCGPAP was administered continuously for 14 days at high, medium and low doses (2.25, 1.125, 0.562 5 mL/kg, converted into raw dosage of 46.44, 23.22, 11.61 g/kg). The effects of MCGPAP on body mass, mating ability, sperm number and gonadal index of normal rats were examined. The effects of single and continuous administration of MCGPAP on body mass, erectile function and gonadal index of rats with kidney-yang deficiency were examined. Results MCGPAP had no significant effect on body mass and gonad index of normal rats; compared with blank control group, high, medium and low doses of MCGPAP could increase insertion times and ejaculation times within 30 minutes (P<0.05); middle doses could also shorten insertion latency, high doses could increase sperm numbers of normal rats, which were significantly different from blank control group and solvent control group (P<0.05). For kidney yang deficiency rats, single dose of MCGPAP had no significant effect on erectile function and body mass; 14 days of MCGPAP administration had no significant effect on body mass of rats; compared with model group, middle dose of MCGPAP could increase erectile percentage and erectile times (P<0.05); kidney index of low dose group was significantly higher than model group and solvent control group (P<0.05); prostate + seminal vesicle gland index was significantly higher than that of model group and solvent control group (P<0.05). Compared with the solvent control group, the number increased significantly (P<0.05). Conclusion s It shows that mountain cultivated ginseng prescription has the function of enhancing mating function of normal rats and erectile function of kidney yang deficiency rats.