目的 研究維生素D聯(lián)合沙丁胺醇治療小兒支氣管哮喘的效果。方法 選擇2014年1月-2016年12月鄭州大學(xué)附屬兒童醫(yī)院的79例小兒支氣管哮喘患兒，隨機(jī)分為兩組。對(duì)照組（n=40）采用壓縮霧化吸入沙丁胺醇治療，觀察組（n=39）在對(duì)照組基礎(chǔ)上聯(lián)合口服維生素D。治療90 d，比較兩組的治療有效率、喘憋癥狀消失時(shí)間、咳嗽緩解時(shí)間、肺部哮鳴音消失時(shí)間和肺部濕啰音消失時(shí)間。結(jié)果 觀察組患兒的有效率明顯高于對(duì)照組，差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后兩組的血清25-羥維生素D3水平均明顯升高，嗜酸細(xì)胞陽離子蛋白（ECP）及血清特異性IgE水平均明顯降低，同組治療前后比較差異均有統(tǒng)計(jì)學(xué)意義（P<0.05）；且觀察組更為明顯，組間比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。觀察組的喘憋癥狀消失時(shí)間、咳嗽緩解時(shí)間、肺部哮鳴音消失時(shí)間和肺部濕啰音消失時(shí)間均明顯短于對(duì)照組，差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。結(jié)論 維生素D聯(lián)合沙丁胺醇對(duì)小兒支氣管哮喘具有較為滿意的治療效果，可以有效改善患兒的臨床癥狀，其作用機(jī)制可能與提高血清25-羥維生素D3水平，降低ECP和Ig E水平有關(guān)。

Objective To study the effect of Effect of vitamin D combined with salbutamol on children with bronchial asthma. Methods Selected 79cases of patients with bronchial asthma who were treated in our hospital from January 2014 to December 2016, divided into two groups randomly. The control group was treated with aerosol inhalation of salbutamol, and the observation group was given vitamin D. The time of wheezing and disappearance of symptoms, the time of cough relieving, the time of disappearing of pulmonary wheezing and the time of pulmonary wet rales disappeared were compared between the two groups.Results The effective rate of the observation group was significantly higher than control group (P<0.05). The levels of serum 25-hydroxyvitamin D3 in the two groups increased significantly (P<0.05), while the ECP and Ig E water decreased significantly (P<0.05), and the observation group was more obvious (P<0.05). The disappearance time of asthmatic symptoms, the time of cough remission, the disappearance time of lung wheezing sound and the loss of lung rale were significantly shorter in the observation group than in the control group (P<0.05).Conclusion Vitamin D combined with salbutamol has a more satisfactory therapeutic effect on bronchial asthma in children. It can effectively improve the clinical symptoms of children. Its mechanism may be related to improving the level of serum 25-hydroxyvitamin D3 and reducing the level of ECP and Ig E.